•Mode I and mode III fracture of plain and forta-ferro fiber reinforced concretes were studied using ENDB specimen.•Crack growth behavior of tested concrete was significantly dependent on the loading ...type and fiber content.•While KIc was greater than KIIIc for all tested concretes, the mode III fracture energy value was higher than mode I case.•Fiber reinforced concrete exhibited excellent post peak failure response under both modes I and III.
This paper investigates the mode I (i.e. tensile) and mode III (i.e. tearing) fracture behavior of concrete composites containing synthetic forta-ferro (SFF) fibers. By employing a simple and suitable test specimen called edge notched disc bend (ENDB) specimen, the effect of adding different percentages of SFF additive on fracture load, fracture toughness and work of fracture was studied experimentally under both pure mode I and pure mode III. A number of unique and useful experimental results were obtained in this research for crack growth resistance of plain and fiber reinforced composite concretes subjected to pure modes I and III loading conditions. It was observed that the fracture initiation and propagation stages are significantly affected by the SFF content. In comparison with the ordinary and plain cement concrete which is manufactured with no fiber additive, the SFF fiber reinforced concrete composite showed higher fracture toughness and work of fracture values. This demonstrates the improved performance of SFF fiber reinforced concretes against cracking under both tensile and tear loads. However, the fracture behavior of tested ENDB specimens made of concrete composites was dependent on the loading mode type (i.e. I or III) and also the SFF content. According to the experimental results the influence of SFF fibers on enhancing mode III fracture toughness was noticeably greater than the pure mode I case and for both loading modes the highest fracture toughness values (i.e. KIc and KIIIc) were obtained for those concrete composites containing 0.3% SFF. In addition, while the magnitude of KIc was greater than the corresponding value of KIIIc for all tested concrete composites, the fracture energy (or work of fracture) of mode III specimens were significantly higher than the mode I specimens. Indeed, the SFF fiber reinforced concrete composites exhibited excellent post peak failure response such that due to resistance of SFF fibers agains applied loads significant amount of energy was required for overall breakage of tested concretes. This ability can be considered as an advantage of SFF fiber reinforced concrete materials for designing earthquake-resistant structures.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
We aimed to characterize in vivo α-synuclein (α-syn) aggregates in skin nerves to ascertain: 1) the optimal marker to identify them; 2) possible differences between synucleinopathies that may justify ...the clinical variability. We studied multiple skin nerve α-syn deposits in 44 patients with synucleinopathy: 15 idiopathic Parkinson's disease (IPD), 12 dementia with Lewy Bodies (DLB), 5 pure autonomic failure (PAF) and 12 multiple system atrophy (MSA). Ten healthy subjects were used as controls. Antibodies against native α-syn, C-terminal α-syn epitopes such as phosphorylation at serine 129 (p-syn) and to conformation-specific for α-syn mature amyloid fibrils (syn-F1) were used. We found that p-syn showed the highest sensitivity and specificity in disclosing skin α-syn deposits. In MSA abnormal deposits were only found in somatic fibers mainly at distal sites differently from PAF, IPD and DLB displaying α-syn deposits in autonomic fibers mainly at proximal sites. PAF and DLB showed the highest p-syn load with a widespread involvement of autonomic skin nerve fibers.
1) p-syn in skin nerves was the optimal marker for the in vivo diagnosis of synucleinopathies; 2) the localization and load differences of aggregates may help to identify specific diagnostic traits and support a different pathogenesis among synucleinopathies.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
This trial enlisted 14 patients with pure red-cell aplasia and antierythropoietin antibodies that were induced by treatment with conventional erythropoiesis-stimulating agents. The patients were ...treated with a peptide-based erythropoietin-receptor agonist that simulates the action of erythropoietin. Of the 14 subjects, 13 achieved a hemoglobin concentration above 11 g per deciliter and over the 28-month course of the study lost the need for regular transfusions.
Patients with pure red-cell aplasia were treated with a peptide-based erythropoietin-receptor agonist that simulates the action of erythropoietin. Of the 14 subjects, 13 achieved a hemoglobin concentration above 11 g per deciliter and over the 28-month course of the study lost the need for regular transfusions.
The induction of neutralizing antierythropoietin antibodies is a rare complication of the use of recombinant human erythropoietin to increase red-cell production in patients with the anemia of chronic renal failure. Such antibodies can cause pure red-cell aplasia.
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They neutralize not only epoetin and darbepoetin alfa but also the patient's own erythropoietin. In severe cases of antibody-mediated pure red-cell aplasia there are virtually no erythroblasts in the bone marrow, the reticulocyte count is less than 10×10
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per liter, and the patient is reliant on transfusions.
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The neutralizing antierythropoietin antibodies, which are largely of the IgG1 or IgG4 subtype, are directed . . .
This textbook is intended for courses in aphasia and other neurogenic communication disorders. The Coursebook offers a comprehensive description and critical review of basic and applied research on ...aphasia, right hemisphere disorder (RHD), traumatic brain injury (TBI), and dementia--the four major language and communication disorders associated with neurological pathologies. The relationship between the brain and language, major features of aphasia and other disorders, their assessment, and treatment have been described in streamlined and clinician-friendly language. Critical review of theories, assessment, and treatment research helps speech-language pathologists distinguish valid from the questionable in the professional and scientific literature. All assessment and treatment chapters give an outline of comprehensive and practical procedures, integrating current practices that clinicians might readily use.
α-Synucleinopathies are characterized by autonomic dysfunction and motor impairments. In the pure autonomic failure (PAF), α-synuclein (α-Syn) pathology is confined within the autonomic nervous ...system with no motor features, but mouse models recapitulating PAF without motor dysfunction are lacking. Here, we show that in TgM83
mice, inoculation of α-Syn preformed fibrils (PFFs) into the stellate and celiac ganglia induces spreading of α-Syn pathology only through the autonomic pathway to both the central nervous system (CNS) and the autonomic innervation of peripheral organs bidirectionally. In parallel, the mice develop autonomic dysfunction, featured by orthostatic hypotension, constipation, hypohidrosis and hyposmia, without motor dysfunction. Thus, we have generated a mouse model of pure autonomic dysfunction caused by α-Syn pathology. This model may help define the mechanistic link between transmission of pathological α-Syn and the cardinal features of autonomic dysfunction in α-synucleinopathy.
•Several ML models are utilized to estimate MMP for pure CO2 flooding.•Diverse data with various conditions and independent parameters are included.•Sensitivity analysis and the impact of parameters ...are investigated.•ML models are more effective and reliable in predicting the MMP of pure CO2 injection.
CO2 injection for enhanced oil recovery (EOR) is widely recognized as an efficient technique for carbon capture, utilization, and storage (CCUS). This operation has a significant impact on various technical parameters, emphasizing the need to carefully consider and select the optimum approach. Among these factors, the minimum miscible pressure (MMP) plays a crucial role in determining the effectiveness and performance of CO2 injection. Therefore, this study aims to assess the reliability of machine learning (ML) in predicting the MMP of pure CO2 and examine the influence of different independent parameters. To achieve this, five ML methods were employed to predict the pure CO2 MMP, and the results were compared to statistical evaluations based on empirical correlations. In addition, three types of data with different functional input parameters were used in this research. Two types of data were obtained from existing literature, while the third category was collected from the thesis and PVT reports for specific Iraqi oil fields. The ML models were constructed by splitting the dataset into 20% for testing and 80% for training using Python programming. The significance of this study lies in its ability to identify the most efficient approach for forecasting MMP. The results of this work revealed that the K-nearest neighbors (KNN) model indicated the best statistical evaluation among the ML learning algorithms for two types of data (2) and (3) in predicting the MMP for pure CO2 flooding. This was evidenced by the lowest mean square error and the highest coefficient of determination. Additionally, the findings indicated that the support vector regression (SVR) method is an effective technique for smaller datasets. Moreover, the sensitivity analysis and assessment of the relative impacts of various input parameters revealed that the prediction of MMP is most sensitive to the composition of the injected gas and temperature, accounting for 46% and 28.5% of the variation, respectively. Finally, the presented ML models indicate exceptional accuracy, speed, adaptability in handling diverse conditions, and cost-effectiveness when compared to conventional approaches. These results verify the ability of ML models to provide high-quality predictions.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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•Direct Extraction of the Heteronuclear coupling with High abundant nuclei.•Magnitude of the coupling can be measure straightforward with separation within doublet.•Proposed method ...will helpful in understanding the structure and dynamics of modern organic chemistry.
Determination of dihedral angles from heteronuclear nJHX couplings (where n is 2, 3 or 4 and X stands for 31P, 19F, etc.) is very useful in structure elucidation. It is a challenging task to extract these couplings from 1D 1H NMR spectra due to the presence of a large number of nJHH and nJHX. Herein, we demonstrate the utility of two different pure shift NMR methods wherein 1H–1H multiplets are collapsed into singlets, revealing only nJHX in the spectrum. The benefit of DFT calculations for prediction of these couplings and congruence with their experimental counterparts is also demonstrated.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
To report a case of pure red-cell aplasia secondary to pregnancy and to conduct a review of the literature regarding diagnosis and treatment, as well as maternal and perinatal prognosis.
This is the ...case of a 24-year-old patient at 34 weeks of gestation, referred to a regional public referral hospital due to anemia. Bone marrow biopsy was performed, leading to the diagnosis of pregnancy-related pure red-cell aplasia. The patient received serial red blood cell transfusions. Delivery by Cesarean section at term resulted in a healthy newborn. Hemoglobin values remained stable during the postoperative period. A literature search was conducted in Medline via PubMed, LILACS, SciELO and ScienceDirect using the terms "pregnancy" and "pure red-cell aplasia". Case reports, case series and literature reviews in English and Spanish published between January 1999 and January 2020 that report pregnant women with pure red-cell aplasia were included. Information on diagnosis, treatment and maternal and perinatal prognosis was collected. Three of the authors selected the studies by title and abstract; A descriptive synthesis is provided.
Overall, 828 titles were identified; of these,818 were discarded after reviewing the inclusions criteria. Ten articles were included: six case reports, three case reports with literature review, and one case report in the poster modality, for a total number of 10 reported cases. Diagnosis was based on low hemoglobin levels and compromised erythroid cell line in bone marrow biopsy. Treatment consists of red blood cell transfusions, with good maternal and fetal prognosis.
Diagnosis of pure red-cell aplasia during pregnancy requires bone marrow biopsy. With transfusion support, maternal perinatal prognosis is good. Further studies are required to assess the safety and efficacy of steroid use in this pregnancy-related condition.
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