Metals and alloys, including stainless steel, titanium and its alloys, cobalt alloys, and other metals and alloys have been widely used clinically as implant materials, but implant-related infection ...or inflammation is still one of the main causes of implantation failure. The bacterial infection or inflammation that seriously threatens human health has already become a worldwide complaint. Antibacterial metals and alloys recently have attracted wide attention for their long-term stable antibacterial ability, good mechanical properties and good biocompatibility in vitro and in vivo. In this review, common antibacterial alloying elements, antibacterial standards and testing methods were introduced. Recent developments in the design and manufacturing of antibacterial metal alloys containing various antibacterial agents were described in detail, including antibacterial stainless steel, antibacterial titanium alloy, antibacterial zinc and alloy, antibacterial magnesium and alloy, antibacterial cobalt alloy, and other antibacterial metals and alloys. Researches on the antibacterial properties, mechanical properties, corrosion resistance and biocompatibility of antibacterial metals and alloys have been summarized in detail for the first time. It is hoped that this review could help researchers understand the development of antibacterial alloys in a timely manner, thereby could promote the development of antibacterial metal alloys and the clinical application.
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•This paper focuses the recent development of several antibacterial metals and alloys as biomedical materials.•The possible antibacterial mechanisms of antibacterial metals and alloys are summarized in this paper.•This review discusses the feasibility of antibacterial metals and alloys as biomedical implants in the future.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Bacterial infection is one of the most serious threats to public health. Despite traditional antibiotics therapy provides an effective approach to combat pathogenic bacteria, the long-term use and ...overuse of antibiotics result in the evolution of bacteria with antibiotic resistance. Recent progress in nanotechnology offers novel opportunities to overcome the obstacle with independence of antibiotics. Metal-organic frameworks (MOFs) have emerged as new tools to combat bacterial infection in biomedical and food packaging fields.
This review comprehensively summarizes the main antibacterial mechanisms of MOFs and their derived nanomaterials. Besides, the recent progress of MOFs and their derived nanomaterials as various antibacterial agents in biomedicine and food packaging is highlighted in detail (period 2016–2020). Meantime, the advantages and disadvantages of MOFs for antibacterial application are proposed. In the end, we discuss the current challenges and future development prospects to promote the further research of MOFs-based nanomaterials in antibacterial applications.
MOFs are a class of crystalline porous materials with high surface areas, tunable porosity and flexible skeletons. Recently, MOFs and their derived nanomaterials, such as hybrid MOFs, MOFs membranes, nanozymes, single-atom nanozymes (SAzymes), etc. have attracted extensive attention due to their remarkable antibacterial activity. The superior antibacterial propertiers mainly rely on physical contact, metal ions and ligands, oxidative stress, photothermal effect and synergistic effect. Among the diverse forms and antibacterial mechanisms, hybridized and modified MOFs show enhanced or target-controlled antibacterial capacity, which will be more accurate and preferred in practical application. Additionally, the characters of easy modification, biocompatibility and biodegradability can facilitate the application of MOFs-based nanomaterials. Although employing MOFs and their derived nanomaterials as antibacterial agents is still in the preliminary stage and needs further exploration, it provides new avenues and displays great prospects in biomedicine and food packaging fields.
•The antibacterial mechanisms of MOFs-based nanomaterials are summarized.•The recent advances of MOFs-based nanomaterials as antibacterial agents are comprehensively highlighted.•The further challenges and opportunities are also put forward.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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Antibacterial Mechanism of Curcumin: A Review Zheng, Dantong; Huang, Chongxing; Huang, Haohe ...
Chemistry & biodiversity,
August 2020, 2020-08-00, 20200801, Volume:
17, Issue:
8
Journal Article
Peer reviewed
Curcumin is a plant‐derived polyphenolic active substance with broad‐spectrum antibacterial properties. Curcumin blocks bacterial growth owing to its structural characteristics and the generation of ...antioxidation products. Curcumin can inhibit bacterial virulence factors, inhibit bacterial biofilm formation and prevent bacterial adhesion to host receptors through the bacterial quorum sensing regulation system. As a photosensitizer, curcumin acts under blue light irradiation to induce phototoxicity and inhibit bacterial growth. Moreover, it can exert a synergistic antibacterial effect with other antibacterial substances. In this review, we summarize the research progress on the antibacterial mechanism of curcumin based on five targeting structures and two modes of action. Our discussion provides a theoretical basis and technical foundation for the development and application of natural antibacterial agents.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Bacterial infections remain the leading cause of death worldwide today. The emergence of antibiotic resistance has urged the development of alternative antibacterial technologies to complement or ...replace traditional antibiotic treatments. In this regard, metal nanomaterials have attracted great attention for their controllable antibacterial functions that are less prone to resistance. This review discusses a particular family of stimuli-activable metal-bearing nanomaterials (denoted as SAMNs) and the associated on-demand antibacterial strategies. The various SAMN-enabled antibacterial strategies stem from basic light and magnet activation, with the addition of bacterial microenvironment responsiveness and/or bacteria-targeting selectivity and therefore offer higher spatiotemporal controllability. The discussion focuses on nanomaterial design principles, antibacterial mechanisms, and antibacterial performance, as well as emerging applications that desire on-demand and selective activation (i.e., medical antibacterial treatments, surface anti-biofilm, water disinfection, and wearable antibacterial materials). The review concludes with the authors’ perspectives on the challenges and future directions for developing industrial translatable next-generation antibacterial strategies.
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IJS, KILJ, NUK, PNG, UL, UM
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Antimicrobial hydrogels have been proposed to be interesting materials used for wound healing due to their unique properties. Therefore, numerous scientists have made efforts to ...design and synthesize antibacterial hydrogels. At present, there are two commonly used methods for preparing antibacterial hydrogels. One is combining antibacterial agents with hydrogels. Antibacterial drugs include antibiotics, some biological extracts, natural polymers and some metal nanoparticles. In this review, physical combination (directly incorporating, swelling diffusion method, encapsulated in carriers) and chemical combination (hydrogels with inherent antibacterial activity, forming chemical bonds) are introduced depending on the methods and types of antibacterial agents incorporated with hydrogels. The other one is light-assisted antibacterial hydrogels, which involve photo-thermal antibacterial hydrogels and photo-dynamic antibacterial hydrogels. The common methods to prepare light-assisted antibacterial hydrogels are also described in this work. With the rapid improvements in antibacterial technology, many novel antibacterial hydrogels are constantly emerging. The most relevant studies and the latest status of research in this area were evaluated in this review.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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•AgGO with enhanced absorption in the visible spectrum through a single-step surfactant-free facile method was prepared.•WO3-x/AgrGO composite with better photocatalytic activity was ...prepared by doping WO3-x by AgGO via a hydrothermal process.•Better carrier separation and reduced impedance leading to RhB degradation and bacterial inactivation.•It exhibits versatilities for photocatalytic activities in visible regions.•Stability tests suggest its excellent reusability.
Suppressing charge recombination in semiconductors via triggering interfacial polarization and synergism provides an effective way to redeem multifunctionality and achieve environmental sustainability. Herein, we anchor a single-step facile synthesis of AgGO, providing bandgap control through varying oxidation time and subsequent simultaneous incorporation of Ag and rGO via the in situ hydrothermal method in WO3-x. The resulting WO3-x/AgrGO composite demonstrated a broadening of optical absorption and excellent suppression of carrier recombination, thereby improving the catalytic properties. The synergism and excellent conductivity of AgrGO enhance the interfacial polarization to store the carriers for longer times and help carriers carry most of their energy to the catalyst’s surface. When WO3-x/AgrGO was tested against RhB under visible light irradiation, its degradation constant reached 0.034/min, 7.4 times faster than pure WO3-x. It has left no viable bacteria during the photoinactivation of gram-negative E. coli bacteria, and even its inactivation rate is 1.07 times faster than AgGO. So, this study provides a direct method of metal-GO composite synthesis and subsequent introduction into WO3-x to broaden the versatility of environmental semiconductors.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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•Lipopeptide type biosurfactant was isolated from Bacillus tequilensis strain SDS21.•Biosurfactant exhibited bactericidal and biofilm dislodging activity.•Biosurfactant removed ...biofilm from glass, stainless steel and polystyrene surface.•Exposure to extreme pH and temperature has no influence on biosurfactant activity.•Biosurfactant retained its bactericidal and anti-biofilm activity in hard water.
Antiseptics and disinfectants are widely applied for eliminating microorganisms. However, microorganisms dwelling in the biofilm are less susceptible and in some cases resistant to biocide treatment. The present study describes isolation and characterization of lipopeptide biosurfactant exhibiting disinfectant-like activity. Biosurfactant was produced by an endo-rhizospheric bacterium Bacillus tequilensis strain SDS21. Biosurfactant reduced the surface tension of water from 72 to 30 mN/m with CMC of 40 mg/l. The Liquid Chromatography–Mass Spectrometry analysis of biosurfactant suggested it to be a mixture of C14, C15, C16 and C17 surfactin homologues. The lipopeptide biosurfactant exhibited bactericidal activity against planktonic cells and biofilm residing sessile cells. The biosurfactant treatment eradicated more than 99% of bacterial biofilm present on polystyrene, glass and stainless steel surface. The biosurfactant retained its bactericidal and biofilm eradicating activities even after exposure to extreme conditions like high temperate and extreme pH. Unlike some of the commonly used disinfectant, biosurfactant retained its bactericidal and biofilm removing activity even in the hard water containing Mg2+ and Ca2+ ions. Thus, suggesting that biosurfactant produced by strain SDS21 can be used as a disinfectant or in disinfectant-like formulations effective against both planktonic and biofilm residing bacteria.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The increase of antibiotic resistance in bacteria has become a major concern for successful diagnosis and treatment of infectious diseases. Over the past few decades, significant progress has been ...achieved on the development of nanotechnology‐based medicines for combating multidrug resistance in microorganisms. Among this, silver nanoparticles (AgNPs) hold great promise in addressing this challenge due to their broad‐spectrum and robust antimicrobial properties. This review illustrates the antibacterial mechanisms of silver nanoparticles and further elucidates how different structural factors including surface chemistry, size, and shape, impact their antibacterial activities, which are expected to promote the future development of more potent silver nanoparticle‐based antibacterial agents.
Silver nanoparticles (AgNPs) hold great promise to address the challenges in multidrug resistance in bacteria. This review briefly summarizes the current understanding of antibacterial mechanisms of AgNPs and how surface chemistry, size, and shape, impact their potencies, which are expected to help further development of AgNP‐based antibacterial agents.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
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