Motivation
The emergence of a novel strain of betacoronavirus, SARS-CoV-2, has led to a pandemic that has been associated with over 700 000 deaths as of August 5, 2020. Research is ongoing around the ...world to create vaccines and therapies to minimize rates of disease spread and mortality. Crucial to these efforts are molecular characterizations of neutralizing antibodies to SARS-CoV-2. Such antibodies would be valuable for measuring vaccine efficacy, diagnosing exposure and developing effective biotherapeutics. Here, we describe our new database, CoV-AbDab, which already contains data on over 1400 published/patented antibodies and nanobodies known to bind to at least one betacoronavirus. This database is the first consolidation of antibodies known to bind SARS-CoV-2 as well as other betacoronaviruses such as SARS-CoV-1 and MERS-CoV. It contains relevant metadata including evidence of cross-neutralization, antibody/nanobody origin, full variable domain sequence (where available) and germline assignments, epitope region, links to relevant PDB entries, homology models and source literature.
Results
On August 5, 2020, CoV-AbDab referenced sequence information on 1402 anti-coronavirus antibodies and nanobodies, spanning 66 papers and 21 patents. Of these, 1131 bind to SARS-CoV-2.
Availabilityand implementation
CoV-AbDab is free to access and download without registration at http://opig.stats.ox.ac.uk/webapps/coronavirus. Community submissions are encouraged.
Supplementary information
Supplementary data are available at Bioinformatics online.
Presents the state of the technology, from fundamentals to new materials and applications Today's electronic devices, computers, solar cells, printing, imaging, copying, and recording technology, to ...name a few, all owe a debt to our growing understanding of the photophysics and photochemistry of polymeric materials. This book draws together, analyzes, and presents our current understanding of polymer photochemistry and photophysics. In addition to exploring materials, mechanisms, processes, and properties, the handbook also highlights the latest applications in the field and points to new developments on the horizon. Photochemistry and Photophysics of Polymer Materials is divided into seventeen chapters, including: Optical and luminescent properties and applications of metal complex-based polymers Photoinitiators for free radical polymerization reactions Photovoltaic polymer materials Photoimaging and lithographic processes in polymers Photostabilization of polymer materials Photodegradation processes in polymeric materials Each chapter, written by one or more leading experts and pioneers in the field, incorporates all the latest findings and developments as well as the authors' own personal insights and perspectives. References guide readers to the literature for further investigation of individual topics. Together, the contributions represent a series of major developments in the polymer world in which light and its energy have been put to valuable use. Not only does this reference capture our current state of knowledge, but it also provides the foundation for new research and the development of new materials and new applications.
This book discusses the historical networking environment that gave rise to SDN, as well as the latest advances in SDN technology. It provides state of the art knowledge needed for successful ...deployment of an SDN, including how to explain to the non-technical business decision makers in an organization the potential benefits and risks, in shifting parts of a network to the SDN model; how to make intelligent decisions about when to integrate SDN technologies in a network; how to decide if an organization should be developing its own SDN applications or looking to acquire them from an outside vendor; how to accelerate the ability to develop an SDN application; discusses the evolution of the switch platforms that enable SDN; addresses when to integrate SDN technologies in a network; provides an overview of sample SDN applications relevant to different industries; includes practical examples of how to write SDN applications. --
Specialty Optical Fibers Handbook Alexis Mendez, T. F. Morse / Alexis Mendez, T. F. Morse
2007, 2011, 2006-12-15T00:00:00, 2011-10-10
eBook
This book is a comprehensive contributed volume that aims to describe and explain the design, fabrication, operating characteristics, and specific applications of the most popular and useful types of ...specialty optical fibers. These 'specialty fibers' include any kind of optical fiber that has been architecturally manipulated to diverge from a conventional structure. For instance, metal-coated fibers can be utilized for bandwidth improvement, and hollow core fibers offer more controllable dispersion for sensitive medical procedures.
Applications for these specialty fibers abound in the biomedical, sensors, and industrial fields, as well as in more traditional communications capacities. This book will act as a specialty fiber 'guided tour', hosted by the top names in the discipline.
The author studies continuous processes indexed by a special family of graphs. Processes indexed by vertices of graphs are known as probabilistic graphical models. In 2011, Burdzy and Pal proposed a ...continuous version of graphical models indexed by graphs with an embedded time structure-- so-called time-like graphs. The author extends the notion of time-like graphs and finds properties of processes indexed by them. In particular, the author solves the conjecture of uniqueness of the distribution for the process indexed by graphs with infinite number of vertices. The author provides a new result showing the stochastic heat equation as a limit of the sequence of natural Brownian motions on time-like graphs. In addition, the author's treatment of time-like graphical models reveals connections to Markov random fields, martingales indexed by directed sets and branching Markov processes.
Abstract
Summary
We present an updated version of our computational pipeline, PathSeq, for the discovery and identification of microbial sequences in genomic and transcriptomic libraries from ...eukaryotic hosts. This pipeline is available in the Genome Analysis Toolkit (GATK) as a suite of configurable tools that can report the microbial composition of DNA or RNA short-read sequencing samples and identify unknown sequences for downstream assembly of novel organisms. GATK PathSeq enables sample analysis in minutes at low cost. In addition, these tools are built with the GATK engine and Apache Spark framework, providing robust, rapid parallelization of read quality filtering, host subtraction and microbial alignment in workstation, cluster and cloud environments.
Availability and implementation
These tools are available as a part of the GATK at https://github.com/broadinstitute/gatk.
Supplementary information
Supplementary data are available at Bioinformatics online.
With the recent emphasis on green chemistry in the chemical industries, there is the need for environmentally friendly large-scale syntheses. This book lays out an important catalytic reaction class ...for these green/sustainable reactions, covering catalyst characterization and performance as well as paying special attention to catalyst stability and recyclability. An international team of authors guides readers in the selection, preparation, and use of catalysts for industrial organic synthesis in the pharmaceutical, fragrance, fine chemical, and petrochemical industries.
The microservice architecture is sweeping the world as the de facto pattern with which to design and build scalable, easy-tomaintain web applications. This book will teach you common patterns and ...practices, and will show you how to apply these using the Clojure programming language. This book will teach you the fundamental concepts of architectural design and RESTful communication, and show you patterns that provide manageable code that is supportable in development and at scale in production. We will provide you with examples of how to put these concepts and patterns into practice with Clojure. This book will explain and illustrate, with practical examples, how teams of all sizes can start solving problems with microservices. You will learn the importance of writing code that is asynchronous and non-blocking and how Pedestal helps us do this. Later, the book explains how to build Reactive microservices in Clojure that adhere to the principles underlying the Reactive Manifesto. We finish off by showing you various ways to monitor, test, and secure your microservices. By the end, you will be fully capable of setting up, modifying, and deploying a microservice with Clojure and Pedestal.
Laser induced breakdown spectroscopy (LIBS) is basically an emission spectroscopy technique where atoms and ions are primarily formed in their excited states as a result of interaction between a ...tightly focused laser beam and the material sample. The interaction between matter and high-density photons generates a plasma plume, which evolves with time and may eventually acquire thermodynamic equilibrium. One of the important features of this technique is that it does not require any sample preparation, unlike conventional spectroscopic analytical techniques. Samples in the form of solids, liquids, gels, gases, plasmas and biological materials (like teeth, leaf or blood) can be studied with almost equal ease. LIBS has rapidly developed into a major analytical technology with the capability of detecting all chemical elements in a sample, of real- time response, and of close- contact or stand-off analysis of targets. The present book has been written by active specialists in this field, it includes the basic principles, the latest developments in instrumentation and the applications of LIBS. It will be useful to analytical chemists and spectroscopists as an important source of information and also to graduate students and researchers engaged in the fields of combustion, environmental science, and planetary and space exploration.* Recent research work * Possible future applications * LIBS Principles
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