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41.
  • Frontiers in New Drug Disco... Frontiers in New Drug Discovery
    2023
    eBook
    Open access

    The intention of this Special Issue is to focus on new aspects of drug discovery, including the search for new molecular targets of various diseases, the creation of new modern methods for diagnosing ...
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42.
  • Potential Nutraceutical Pro... Potential Nutraceutical Properties of Leaves from Several Commonly Cultivated Plants
    Amat-Ur-Rasool, Hafsa; Symes, Fenella; Tooth, David ... Biomolecules (Basel, Switzerland), 11/2020, Volume: 10, Issue: 11
    Journal Article
    Peer reviewed
    Open access

    Chronic dietary ingestion of suitable phytochemicals may assist with limiting or negating neurodegenerative decline. Current therapeutics used to treat Alzheimer disease elicit broad adverse drug ...
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43.
  • Recent Developments in Chol... Recent Developments in Cholinesterases Inhibitors for Alzheimers Disease Treatment
    MUSIAŁ, Anna; BAJDA, Marek; MALAWSKA, Barbara Current medicinal chemistry, 10/2007, Volume: 14, Issue: 25
    Journal Article
    Peer reviewed

    Alzheimers disease (AD) is a progressive neurodegenerative disorder of the central nervous system (CNS) which is the most common cause of dementia in the elderly. It is characterized by the deficits ...
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Available for: NUK, UL
44.
  • Anti‐Alzheimer's multitarge... Anti‐Alzheimer's multitarget‐directed ligands with serotonin 5‐HT6 antagonist, butyrylcholinesterase inhibitory, and antioxidant activity
    Marcinkowska, Monika; Bucki, Adam; Panek, Dawid ... Archiv der Pharmazie (Weinheim), July 2019, 20190701, Volume: 352, Issue: 7
    Journal Article
    Peer reviewed

    Serotonin 5‐HT6 receptors, butyrylcholinesterase (BuChE) and oxidative stress are related to the pathophysiology of Alzheimer's disease. Inhibition of BuChE provides symptomatic treatment of the ...
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Available for: BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
45.
  • Cholinesterases Inhibition ... Cholinesterases Inhibition by Novel cis - and trans -3-Arylaminocyclohexyl N , N -Dimethylcarbamates: Biological Evaluation and Molecular Modeling
    Yamazaki, Diego A. S.; Cândido, Augusto A.; Bagatin, Mariane C. ... Journal of the Brazilian Chemical Society, 09/2016, Volume: 27, Issue: 9
    Journal Article
    Peer reviewed
    Open access

    The present study describes the synthesis, assessment of the anticholinesterase activity and the inhibition type of novel cis- and trans-3-arylaminocyclohexyl N,N-dimethylcarbamates. In vitro ...
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46.
  • Novel cinnamic acid–tryptam... Novel cinnamic acid–tryptamine hybrids as potent butyrylcholinesterase inhibitors: Synthesis, biological evaluation, and docking study
    Ghafary, Shahrzad; Najafi, Zahra; Mohammadi‐Khanaposhtani, Maryam ... Archiv der Pharmazie (Weinheim), October 2018, 2018-Oct, 2018-10-00, 20181001, Volume: 351, Issue: 10
    Journal Article
    Peer reviewed

    A novel series of cinnamic acid–tryptamine hybrids was designed, synthesized, and evaluated as cholinesterase inhibitors. Anticholinesterase assays showed that all of the synthesized compounds ...
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Available for: BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
47.
  • Quinolizidinyl derivatives ... Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer’s disease
    Tasso, B.; Catto, M.; Nicolotti, O. ... European journal of medicinal chemistry, 06/2011, Volume: 46, Issue: 6
    Journal Article
    Peer reviewed

    On the pattern of the potent and selective butyrylcholinesterase (BChE) inhibitors ethopropazine and Astra1397, sets of quinolizidinyl derivatives of bi- and tricyclic (hetero)aromatic systems were ...
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48.
  • Synthesis, biological evalu... Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinesterase/butyrylcholinesterase
    Tang, Huang; Wei, Yong-Biao; Zhang, Chi ... European journal of medicinal chemistry, 06/2009, Volume: 44, Issue: 6
    Journal Article
    Peer reviewed

    Aporphine alkaloids, isolated from Chinese medicinal herb, are important natural products. We recently reported that synthetic derivatives of oxoisoaporphine alkaloids exhibited high ...
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49.
  • Recent Developments on Multi-Target-Directed Tacrines for Alzheimer's Disease. I. The Pyranotacrines
    Romero, Alejandro; Marco-Contelles, Jose Current topics in medicinal chemistry, 01/2017, Volume: 17, Issue: 31
    Journal Article
    Peer reviewed

    Tacrine was the first drug to display beneficial effects on cognitive impairment of Alzheimer Disease (AD) patients. Unfortunately, many treated patients displayed related hepatotoxicity, and hence ...
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50.
  • Cholinesterase Research Cholinesterase Research
    2021
    eBook
    Open access

    This collection of 10 papers includes original as well as review articles focused on the cholinesterase structural aspects, drug design and development of novel cholinesterase ligands, but also ...
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