Adding three cycles of induction chemotherapy with gemcitabine and cisplatin to concurrent chemoradiotherapy improved 3-year recurrence-free survival (85.3%, vs. 76.5% with concurrent ...chemoradiotherapy alone) and overall survival (94.6% vs. 90.3%). Patients receiving induction chemotherapy were more likely to have grade 3 or 4 myelosuppression, nausea, and vomiting.
Microsatellite instability determines whether patients with gastrointestinal cancer respond exceptionally well to immunotherapy. However, in clinical practice, not every patient is tested for MSI, ...because this requires additional genetic or immunohistochemical tests. Here we show that deep residual learning can predict MSI directly from H&E histology, which is ubiquitously available. This approach has the potential to provide immunotherapy to a much broader subset of patients with gastrointestinal cancer.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Organoids in cancer research Drost, Jarno; Clevers, Hans
Nature reviews. Cancer,
07/2018, Volume:
18, Issue:
7
Journal Article
Peer reviewed
The recent advances in in vitro 3D culture technologies, such as organoids, have opened new avenues for the development of novel, more physiological human cancer models. Such preclinical models are ...essential for more efficient translation of basic cancer research into novel treatment regimens for patients with cancer. Wild-type organoids can be grown from embryonic and adult stem cells and display self-organizing capacities, phenocopying essential aspects of the organs they are derived from. Genetic modification of organoids allows disease modelling in a setting that approaches the physiological environment. Additionally, organoids can be grown with high efficiency from patient-derived healthy and tumour tissues, potentially enabling patient-specific drug testing and the development of individualized treatment regimens. In this Review, we evaluate tumour organoid protocols and how they can be utilized as an alternative model for cancer research.
Immune checkpoint inhibitor (ICI) treatments benefit some patients with metastatic cancers, but predictive biomarkers are needed. Findings in selected cancer types suggest that tumor mutational ...burden (TMB) may predict clinical response to ICI. To examine this association more broadly, we analyzed the clinical and genomic data of 1,662 advanced cancer patients treated with ICI, and 5,371 non-ICI-treated patients, whose tumors underwent targeted next-generation sequencing (MSK-IMPACT). Among all patients, higher somatic TMB (highest 20% in each histology) was associated with better overall survival. For most cancer histologies, an association between higher TMB and improved survival was observed. The TMB cutpoints associated with improved survival varied markedly between cancer types. These data indicate that TMB is associated with improved survival in patients receiving ICI across a wide variety of cancer types, but that there may not be one universal definition of high TMB.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Background and Aim: During the Covid-19 pandemic, the knowledge, attitudes, and practices about COVID-19 infection in gynecologic cancer patients were still limited. This study aimed to explore these ...issues.Methods: Gynecologic cancer patients who attended our gynecologic oncology unit between February and June 2022 were invited to a cross-sectional survey using a WHO survey tool. Results: 363 patients participated with 20.9% undergoing treatment and receiving the COVID-19 vaccine significantly less than the surveillance participants (85.4% vs.57.9%, P < 0.01). Forty-eight participants developed a COVID-19 infection. The most common vaccine used for the two first doses was AstraZeneca. Regarding attitudes issues, most participants felt health literacy was obtained easily. They considered that they had a moderate probability to have severe symptoms of COVID-19 infection and almost all knew the proper behavior for prevention. The participant reported little stress and most trusted healthcare workers and family doctors. They agreed with lifting regular rules to control the COVID-19 pandemic. The other opinions that were significantly higher in participants who did not receive the vaccine versus those who received the vaccine, were as follows: “If everyone is vaccinated, no need for me to vaccinate”, “the stress made me not want to vaccinate”, “no need to vaccine due to rare disease” and “the vaccine is unsafe”. Conclusion: Gynecologic cancer patients who were under treatment received the COVID-19 vaccine less than those under surveillance. Most participants revealed a good attitude toward this pandemic. However, unvaccinated participants were concerned about the severe side effects of the vaccine.
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