Theory Theory of Coherent Raman Scattering, Eric Olaf Potma and Shaul MukamelCoherent Raman Scattering under Tightly Focused Conditions, Eric Olaf Potma, Xiaoliang Sunney Xie, Andreas Volkmer, and ...Ji-Xin ChengPlatformsConstruction of a Coherent Raman Microscope, Brian G. Sarr and Xiaoliang Sunney XieStimulated Raman Scattering Microscopy, Christian Freudiger and Xiaoliang Sunney XieFemtosecond versus Picosecond Pulses for Coherent Raman Microscopy, Mikhail N. Slipchenko, Delong Zhang, and Ji-Xin ChengWide-Field CARS Microscopy, Alexander Jesacher, Gregor Thalhammer, Stefan Bernet, and Monika Ritsch-MarteVibrational Spectromicroscopy by Coupling Coherent Raman Imaging with Spontaneous Raman Spectral Analysis, Mikhail N. Slipchenko and Ji-Xin ChengCoherent Control in CARS, Jonathan M. Levitt, Ori Katz, and Yaron SilberbergFourier Transform CARS Microscopy, Jennifer P. OgilvieCRS with Alternative Beam Profiles, Varun Raghunathan, Hyunmin Kim, Stephan Stranick, and Eric Olaf PotmaVibrational Phase Microscopy, Martin Jurna, Cees Otto, and Herman L. OfferhausMultiplex CARS Microscopy, James P.R. Day, Katrin F. Domke, Gianluca Rago, Erik M. Vartiainen, and Mischa BonnInterferometric Multiplex CARS, Sang-Hyun LimPhotonic Crystal Fiber-Based Broadband CARS Microscopy, Marcus T. Cicerone, Young Jong Lee, Sapun H. Parekh, and Khaled A. AamerMultiplex Stimulated Raman Scattering Microscopy, Dan Fu and Xiaoliang Sunney XieApplicationsImaging Myelin Sheath Ex Vivo and In Vivo by CARS Microscopy, Yan Fu, Yunzhou (Sophia) Shi, and Ji-Xin ChengImaging Lipid Metabolism in Caenorhabditis elegans and Other Model Organisms, Helen Fink, Christian Brackmann, and Annika EnejderLipid-Droplet Biology and Obesity-Related Health Risks, Thuc T. LeWhite Matter Injury: Cellular-Level Myelin Damage Quantification in Live Animals, Erik Bélanger, F.P. Henry, R. Vallée, M.A.
Randolph, I.E. Kochevar, J.M. Winograd, Charles P. Lin, and Daniel CôtéCARS Microscopy Study of Liquid Crystals, Heung-Shik Park and Oleg D. LavrentovichLive Cell Imaging by Multiplex CARS Microspectroscopy, Hideaki Kano Coherent Raman Scattering Imaging of Drug Delivery Systems, Ling Tong and Ji-Xin ChengApplications of Stimulated Raman Scattering Microscopy, Christian Freudiger, Daniel A. Orringer, and Xiaoliang Sunney XieApplications of Coherent Anti-Stokes Raman Spectroscopy Imaging to Cardiovascular Diseases, Han-Wei Wang, Michael Sturek, and Ji-Xin ChengApplications of CARS Microscopy to Tissue Engineering, Annika Enejder and Christian BrackmannDietary Fat Absorption Visualized by CARS Microscopy, Kimberly K. BuhmanIndex.
•Behaviourally-consistent methodologies to study AV adoption decisions is needed.•Study advances and tests four conceptual models of AV adoption behaviour.•Models integrate latent socio-psychological ...and socio-demographic factors.•45 pairs of hypothesized relationships are validated in four measurement models.•Study captures behavioural antecedents to predict AV ownership, sharing and public transit.
Autonomous Vehicles (AVs) have the potential to make motorized transport safer and more sustainable, by integrating clean technologies and supporting flexible shared-mobility services. Leveraging this new form of transport to transform mobility in cities will depend fundamentally on public acceptance of AVs, and the ways in which individuals choose to use them, to meet their daily travel needs. Empirical studies exploring public attitudes towards automated driving technologies and interest in AVs have emerged in the last few years. However, within this strand of research there is a paucity of theory-driven and behaviourally consistent methodologies to unpack the determinants of user adoption decisions with respect to AVs. In this paper, we seek to fill this gap, by advancing and testing four conceptual frameworks which could be deployed to capture the range of possible behavioural influences on individuals’ AV adoption decisions. The frameworks integrate socio-demographic variables and relevant latent behavioural factors, including perceived benefits and perceived ease of use of AVs, public fears and anxieties regarding AVs, subjective norm, perceived behavioural control, and attitudinal factors covering the environment, technology, collaborative consumption, public transit and car ownership. We demonstrate the utility and validity of the frameworks, by translating the latent variables into indicator items in a structured questionnaire, and administering it online to a random sample of adult individuals (n = 507). Using the survey data in confirmatory factor analyses, we specify and demonstrate scale reliability of indicator items, and convergent and discriminant validity of relationships among latent variables. Ultimately, we advance four measurement models. These theory-grounded measurement models are intended for application in research aimed at understanding and predicting (a) AV interest and adoption intentions, and (b) user adoption decisions regarding three different AV modes: ownership, sharing and public transport.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Au Québec, la Société de l’assurance automobile du Québec (SAAQ) est la seule instance responsable de la délivrance d’un permis ou de son retrait.* Récemment, la SAAQ annonçait qu’elle retirait ...l’obligation d’évaluation par un médecin ou un ophtalmologiste/optométriste pour les conducteurs âgés de 75 ans, repoussant cette première évaluation médicale obligatoire à 80 ans (SAAQ, 2021b). On invoque qu’une telle décision permettrait de délester le réseau de la santé d’une charge d’évaluation et de bureaucratie supplémentaire. De plus, il est invoqué que très peu de conducteurs se voyaient retirer leurs permis de conduire à la suite de ces évaluations à la SAAQ. Au cours des dernières années, moins de 2% des personnes âgées de 75 ans voyaient leur permis de conduire suspendu à la suite d’un examen médical ou visuel (SAAQ, 2021a). À cet effet, il est mentionné que la majorité des modifications apportées au droit de conduire portait sur le port de verres correcteurs ou la réduction des heures permises de conduite.
Throughout the last century, the automobile industry achieved remarkable milestones in manufacturing reliable, safe, and affordable vehicles. Because of significant recent advances in computation and ...communication technologies, autonomous cars are becoming a reality. Already autonomous car prototype models have covered millions of miles in test driving. Leading technical companies and car manufacturers have invested a staggering amount of resources in autonomous car technology, as they prepare for autonomous cars' full commercialization in the coming years. However, to achieve this goal, several technical and nontechnical issues remain: software complexity, real-time data analytics, and testing and verification are among the greater technical challenges; and consumer stimulation, insurance management, and ethical/moral concerns rank high among the nontechnical issues. Tackling these challenges requires thoughtful solutions that satisfy consumers, industry, and governmental requirements, regulations, and policies. Thus, here we present a comprehensive review of state-of-the-art results for autonomous car technology. We discuss current issues that hinder autonomous cars' development and deployment on a large scale. We also highlight autonomous car applications that will benefit consumers and many other sectors. Finally, to enable cost-effective, safe, and efficient autonomous cars, we discuss several challenges that must be addressed (and provide helpful suggestions for adoption) by designers, implementers, policymakers, regulatory organizations, and car manufacturers.
What does it mean to trust a technology? Stilgoe, Jack
Science (American Association for the Advancement of Science),
12/2023, Volume:
382, Issue:
6676
Journal Article
Peer reviewed
A survey published in October 2023 revealed what seemed to be a paradox. Over the past decade, self-driving vehicles have improved immeasurably, but public trust in the technology is low and falling. ...Only 37% of Americans said they would be comfortable riding in a self- driving vehicle, down from 39% in 2022 and 41% in 2021. Those that have used the technology express more enthusiasm, but the rest have seemingly had their confidence shaken by the failure of the technology to live up to its hype.
The world continues to strive in the search for clean power sources to run the millions of different vehicles on the road on daily basis as they are the main contributors to toxic emissions releases ...from internal combustion engines to the atmosphere. These toxic emissions contribute to climate change and air pollution and impact negatively on people's health. Fuel cell devices are gradually replacing the internal combustion engines in the transport industry. Some notable challenges of the PEMFC technology are discussed in this paper. High costs, low durability and hydrogen storage problems are some of the major obstacles being examined in this investigation.
The paper explores the latest advances in electric cars technology and their design specifications. The study also compares the characteristics and the technologies of the three types of electric cars now available in the market.
•The work the latest advances in electric cars technology and their design specs.•The paper discusses the advances in the sources of energy for electric cars.•It explores the different propulsion systems currently available.•Control strategies for power management in electric cars are reviewed.•Issues impeding the wide adoption of electric cars by consumers are discussed.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
In order to evaluate the current and future prospects of electric cars’ in Italy, we develop a probabilistic total cost of ownership (TCO) model, which includes stochastic and non-stochastic ...variables, vehicle usage and contextual assumptions. We find that electric cars are currently not cost-competitive in Italy with the conventional petrol or diesel cars. However, they are cost-competitive with the hybrid electric cars when more than 10,000 km are annually traveled. With incentivizing policies (a €5,000 subsidy and a €400 parking and access fee annual savings), currently in place in a limited number of Italian Regions and cities, electric cars perform in monetary terms better than hybrid electric cars and some diesel cars, especially if they are charged at home. However, electric cars are expected to gain market share in the year 2025 if fuel prices follow past trends, even without subsidies. The driving force could be a drop in their retail price, thanks to declining battery pack costs, and a possible revision of the taxes on diesel.
•Develops a probabilistic total cost of ownership model for Italy.•Electric cars are currently not cost-competitive with conventional cars.•With incentivizing policies electric cars perform better than hybrid electric cars.•Electric cars are expected to gain market share in 2025 without subsidies.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
•We study the preferences between an electric and a petrol car in Italy and Slovenia.•We estimate a hybrid mixed logit model with two latent variables.•Higher electric car knowledge increases the ...utility to choose an electric car.•Ceteris paribus, environmentally concerned Italians prefer an electric car.•Informational campaigns on electric cars are recommended for both countries.
We report the results of a stated preference study (N = 1,934) carried out at the end of 2018 on consumers’ choices between electric cars and petrol cars in Italy and Slovenia. We estimate a hybrid mixed logit model that takes into account vehicle, infrastructure and policy attributes and two attitudinal attributes, i.e. environmental awareness and electric car knowledge. We find that purchase price and driving range play a crucial role in consumers’ decisions in both countries, whereas charging time is not statistically significant. Comparing the two countries, price sensitivity is relatively stronger in Italy, while the sensitivity for driving range and fuel economy is relatively stronger in Slovenia. Of the two latent variables we tested, we find that only environmental awareness has a statistically significant positive impact on the choice of electric cars and that it is stronger for Italians compared to Slovenians. The structural component of this latent variable indicates that women are more concerned about the environment than men, but only for the Slovenian subsample. Surprisingly, no statistically significant relationship is found between environmental awareness and age. Younger respondents are as concerned as older ones about the environment both in Italy and in Slovenia.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Although adoptive transfer of chimeric antigen receptor (CAR)-engineered T cells has achieved unprecedented response rates in patients with certain hematological malignancies, this therapeutic ...modality is still far from fulfilling its remarkable potential, especially in the context of solid cancers. Antigen escape variants, off-tumor destruction of healthy tissues expressing tumor-associated antigens (TAAs), poor CAR-T cell persistence, and the occurrence of functional exhaustion represent some of the most prominent hurdles that limit CAR-T cell ability to induce long-lasting remissions with a tolerable adverse effect profile. In this review, we summarize the main approaches that have been developed to face such bottlenecks, including the adapter CAR (AdCAR) system, Boolean-logic gating, epitope editing, the modulation of cell-intrinsic signaling pathways, and the incorporation of safety switches to precisely control CAR-T cell activation. We also discuss the most pressing issues pertaining to the selection of co-stimulatory domains, with a focus on strategies aimed at promoting CAR-T cell persistence and optimal antitumor functionality.
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