To evaluate: 1) the peripheral hearing sensitivity and central auditory processing in persons living with HIV (PWH) and persons living without HIV (PWoH); and 2) the association between cognitive ...function and central auditory processing in PWH and PWoH.
Cross-sectional, observational study.
Participants included 67 PWH (70.2% male; mean age = 66.6 years SD = 4.7 years) and 35 PWoH (51.4% male; mean age = 72.9 years SD = 7.0 years). Participants completed a hearing assessment and a central auditory processing assessment that included dichotic digits testing (DDT). Pure-tone air-conduction thresholds were obtained at octave frequencies from 0.25 through 8 kHz. A pure-tone average (PTA) was calculated from 0.5, 1, 2, and 4 kHz thresholds for each ear. Participants also completed a neuropsychological battery assessing cognition in seven domains.
PWH had slightly lower (i.e., better) PTAs compared to PWoH, but this was not statistically significant. Conversely, PWH and PWoH had similar DDT results for both ears. Poorer verbal fluency, learning, and working memory performance was significantly related to lower DDT scores, and those defined as having verbal fluency, learning, and working memory impairment had significantly poorer DDT scores (8-18% lower) in both ears.
Hearing and DDT results were similar in PWH and PWoH. The relationship between verbal fluency, learning, and working memory impairment and poorer DDT results did not differ by HIV serostatus. Clinicians, particularly audiologists, should be mindful of cognitive functioning abilities when evaluating central auditory processing.
Epilepsy is a clinical manifestation of brain disorder due to various etiologies that needs appopriate treatment. Lack of therapy leade to cognitive impairment. This research aims to evaluate ...cognitive function profile and analyze factors that influence cognitive function in epilepsy patient.
This is a cross sectional study of epilepsy patient in Mohammad Hoesin Hospital Palembang between January–May 2018 that fullfilled inclusion and exclusion criterias assesed by MOCA-Ina and questionnaire. Data was analyzed with SPSS 20.0 Chi-square, ANOVA and correlation for bivariate and double linear regression for multivariate.
Samples consists 39 subjects. The prevalence of cognitive impairment in epilepsy patients was 69.2%. Level of education >9 years was mostly recorded from the samples with MOCA-Ina score that shows cognitive impairment. In multivariate analysis with multiple linear regression tests of 8 variables (age, sex, education level, age of onset, type of epilepsy syndrome, type of drug, duration of seizure, and frequency of seizures), three variables (gender, level of education, duration of seizure) had significant relationship with cognitive function of epilepsy patients. There was also a positive correlation between gender (0,333), education level (0,542) on cognitive function and a negative correlation (−0,334) between the duration of seizure and cognitive function.
The prevalence of cognitive impairment was 69.2% in epilepsy patients at Mohammad Hoeasin hospital Palembang. Level of education, gender and duration of seizure influence cognitive function in epilepsy patient.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Indoor air pollution from solid fuel use might be harmful for cognitive function, while healthy lifestyle is associated with better cognitive function. The extent to which lifestyle modifies the ...association of solid fuel use with cognitive function remains unknown.
A total of 21,008 individuals aged 16 to 92 were enrolled in 2010 and followed up to 2014 in the China Family Panel Studies (CFPS). Cognitive function was assessed using standardized math test and word test in three waves. Solid fuel use was assessed by self-report of firewood, straw, or coal for cooking at baseline. Lifestyle profile was classified into two groups (favorable vs. unfavorable) based on five modifiable lifestyle factors including alcohol drinking, smoking, body mass index, diet, and physical activity. Linear mixed-effects models were employed to assess the association of solid fuel use and lifestyle with cognitive function. The effect modification of lifestyle was analyzed.
A total of 49.7% of the study population used solid cooking fuel and 17.4% had a favorable lifestyle. Solid fuel use was associated with a significant decrease in cognitive function (β = -0.29, 95% CI: -0.39, -0.19 for math test; β = -0.62, 95% CI: -0.84, -0.41 for word test). Lifestyle significantly modified this association (p-interaction: 0.006 for math test; 0.016 for word test), with the corresponding association being less pronounced among participants adhering to a favorable lifestyle compared to those with an unfavorable lifestyle.
A favorable lifestyle may attenuate the negative association of solid fuel use with cognitive function. Adopting a favorable lifestyle has the potential to counteract the adverse neurological effect caused by indoor air pollution.
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•First study examining the interaction between solid fuel use and lifestyle on cognitive function.•Solid fuel use was associated with a significant decrease in cognitive function, with older adults, females, and those from a lower socioeconomic status being more vulnerable.•A favorable lifestyle significantly attenuated the negative association of solid fuel use with cognitive function.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Background: Creatine, a naturally occurring compound plays a crucial role in cellular energy metabolism, particularly in tissues with high energy demands like muscles and the brain. Beyond its ...well-established role in physical performance enhancement, recent research has revealed its potential benefits for cognitive functions and mood regulation. This review paper aims to comprehensively analyze the existing literature on creatine supplementation's effects on cognitive functions and mood. State of Knowledge: Findings suggest that creatine supplementation enhances memory, attention, and executive functions, especially under conditions of stress or sleep deprivation. Moreover, it exhibits mood-stabilizing effects, potentially offering relief for symptoms of depression and fatigue. Creatine's ability to augment brain energy metabolism, alongside its neuroprotective properties, underlies its cognitive and mood-enhancing effects. While generally safe, caution is advised, particularly in populations with kidney diseases or those using medications affecting kidney function. Summary: Creatine emerges as a promising adjunct therapy for enhancing cognitive functions and promoting emotional well-being beyond its traditional role in physical performance.The review underscores the need for further research to elucidate the precise mechanisms of creatine's effects and explore its synergistic potential with other cognitive-enhancing supplements.
Introduction: Considering the importance of agrin, mTOR and AKT proteins in cognitive and physiological function, knowing the effects of different exercise programs is of particular importance. Aim: ...The purpose of this study was to investigate the responses of agrin, mTOR and AKT proteins in dual resistance-cognitive exercises of healthy people. Method: The research method is semi-experimental. 10 healthy men were randomly divided into two groups (resistance-cognitive group of 5 people and resistance group of 5 people). Resistance contraction included eccentric and concentric knee extension with maximum strength and speed. The contractions included 12 sets of 10 repetitions for the right leg, and in the cognitive group, cognitive task exercises included counting numbers in reverse, multiplying and dividing numbers, counting the months of the year, and counting coins simultaneously with facial resistance exercises. Took A biopsy was performed at the beginning and end of the study. To analyze the data, dependent t statistical method and covariance test were performed in SPSS21 software. Results: The results showed that the intra-group changes of mTOR and AKT proteins after one activity session were significant in the resistance-cognitive and resistance groups (p≤0.05). However, the inter-group changes of agrin, mTOR and AKT proteins showed no difference between the two groups. Conclusion: The present study showed that a session of resistance and resistance-cognitive activity leads to changes in the factors involved in the strength and hypertrophy of skeletal muscles. In addition, these changes are generally more resistance-cognitive in the resistance group.
•Vitamin D has been found to be involved in the pathogenesis of cognitive dysfunction in a variety of diseases.•Vitamin D is closely related to the pathophysiological process of epilepsy.•Whether ...vitamin D is associated with epilepsy and cognitive impairment is unclear.
To analyze the correlation between the level of 25(OH)D in peripheral blood and cognitive function in patients with epilepsy, and to find the biomarkers of epilepsy complicated with cognitive dysfunction.
68 patients with epilepsy and 30 healthy subjects were included in this study. The 25(OH)D level in peripheral blood of all subjects was detected and the score of the Montreal Cognitive Assessment Scale was performed. The patients with epilepsy were divided into a cognitively normal group (36 cases) and a cognitively impaired group (32 cases) according to the scale score. The inter-group scale score and 25(OH)D level were compared, and the correlation was analyzed.
The levels of 25(OH)D and MOCA in epileptic group were significantly lower than those in healthy control group. The 25(OH)D and MOCA of the cognitively impaired group were significantly lower than those of the cognitively normal group. Logistic regression analysis indicated that serum 25(OH)D level was an independent risk factor for epilepsy combined with cognitive impairment (OR = 0.704, P = 0.014). The area under ROC curve of serum 25(OH)D for diagnosis of epilepsy combined with cognitive impairment was 0.924 (95 %CI 0.866,0.981), the critical value was 34.50 nmol/L, the sensitivity was 0.778, and the specificity was 0.906.
Decreased levels of vitamin D are associated with cognitive impairment associated with epilepsy, and it may be a biomarker for early screening of cognitive impairment.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Combined probiotic and selenium supplementation may improve Alzheimer's disease (AD) by correcting metabolic abnormalities, and attenuating inflammation and oxidative stress. This study aimed to ...determine the effects of probiotic and selenium co-supplementation on cognitive function and metabolic status among patients with AD.
This randomized, double-blind, controlled clinical trial was conducted among 79 patients with AD. Patients were randomly assigned to receive either selenium (200 μg/day) plus probiotic containing Lactobacillus acidophilus, Bifidobacterium bifidum, and Bifidobacterium longum (2 × 109 CFU/day each) (n = 27), selenium (200 μg/day) (n = 26) or placebo (n = 26) for 12 weeks.
Selenium supplementation, compared with the placebo, significantly reduced serum high sensitivity C-reactive protein (hs-CRP) (P < 0.001), insulin (P = 0.001), homeostasis model of assessment-insulin resistance (HOMA-IR) (P = 0.002), LDL-cholesterol (P = 0.04) and total-/HDL-cholesterol ratio (P = 0.004), and significantly increased total glutathione (GSH) (P = 0.001) and the quantitative insulin sensitivity check index (QUICKI) (P = 0.01). Compared with only selenium and placebo, probiotic and selenium co-supplementation resulted in a significant increase in mini-mental state examination score (+1.5 ± 1.3 vs. +0.5 ± 1.2 and −0.2 ± 1.1, respectively, P < 0.001). Probiotic plus selenium intake resulted in a significant reduction in hs-CRP (−1.6 ± 1.4 vs. −0.8 ± 1.0 and +0.1 ± 0.5 mg/L, respectively, P < 0.001), and a significant increase in total antioxidant capacity (+89.4 ± 129.6 vs. +20.0 ± 62.5 and −0.7 ± 27.2 mmol/L, respectively, P = 0.001) and GSH (+122.8 ± 136.5 vs. +102.2 ± 135.2 and +1.5 ± 53.2 μmol/L, respectively, P = 0.001) compared with only selenium and placebo. In addition, subjects who received probiotic plus selenium supplements had significantly lower insulin levels (−2.1 ± 2.5 vs. −1.0 ± 1.3 and +0.7 ± 2.0 μIU/mL, respectively, P < 0.001), HOMA-IR (−0.5 ± 0.6 vs. −0.2 ± 0.3 and +0.1 ± 0.4, respectively, P < 0.001), and higher QUICKI (+0.01 ± 0.01 vs. +0.005 ± 0.007 and −0.002 ± 0.01, respectively, P < 0.006) compared with only selenium and placebo. Additionally, probiotic and selenium co-supplementation resulted in a significant reduction in serum triglycerides (−17.9 ± 26.1 vs. −3.5 ± 33.9 and +0.3 ± 9.3 mg/dL, respectively, P = 0.02), VLDL- (−3.6 ± 5.2 vs. −0.7 ± 6.8 and +0.05 ± 1.8 mg/dL, respectively, P = 0.02), LDL- (−8.8 ± 17.8 vs. −8.1 ± 19.2 and +2.7 ± 19.0 mg/dL, respectively, P = 0.04) and total-/HDL-cholesterol (−0.3 ± 0.7 vs. −0.4 ± 0.9 and +0.3 ± 0.6, respectively, P = 0.005) compared with only selenium and placebo.
Overall, we found that probiotic and selenium co-supplementation for 12 weeks to patients with AD improved cognitive function and some metabolic profiles.
This study was registered in the Iranian website (www.irct.ir) for registration of clinical trials (http://www.irct.ir: IRCT20170612034497N5).
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Herein, we investigated the effects of Camembert cheese (CC) and its fatty acid contents on cognitive function in mice by employing the object recognition test to evaluate hippocampus-dependent ...memory. Orally administered CC improved the cognitive decline induced by a high-fat diet. Next, we focused on myristamide (MA), oleamide, and stearamide, which are fatty acid amides produced during the fermentation process of CC. We found that oral administration of MA improved cognitive decline. Notably, an improvement was not observed using myristic acid, a free fatty acid that is not amidated. Thus, fatty acid amidation may contribute to the physiological activity. Moreover, we investigated changes in gene expression related to neurogenesis in the hippocampus. After MA administration, mRNA expression analysis indicated that MA increased hippocampal brain-derived neurotrophic factor expression.
•Camembert cheese improved the cognitive decline induced by a high-fat diet.•Myristamide, a molecule present in Camembert cheese, improved cognitive decline.•Amidation contributes to the improvement of cognitive decline.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
