La nécessaire prise en compte des communs, du « mieux être » collectif et des impératifs sociaux et écologiques, comme développé en 2018 dans Kebir, Narath et Wallet (Espaces et Sociétés), conforte ...l’élargissement du champ des acteurs impliqués dans les processus décisionnels constatés dans l’article « La Gouvernance territoriale comme nouveau mode de coordination territoriale ? » (Leloup, Moyart et Pecqueur, 2005). L’enjeu du territoire interroge la fixité arbitraire des espaces administratifs donnés, l’exogénéité perçue de sa croissance ou la passivité supposée de ses habitants, résidents ou autres occupants. Aujourd’hui, comme à l’époque de la publication de l’article précédemment cité, il y a une quinzaine d’années, il entraîne un changement radical de perspective tant pour le modèle de production économique que pour le processus de régulation politique à l’œuvre.
Supply chains (SC) are generally complex and are characterized by numerous activities spread over multiple functions and organizations, which pose interesting challenges for effective SC ...coordination. To meet these challenges, SC members must work towards a unified system and coordinate with each other. A systematic literature review is presented in this paper to throw light on the importance of SC coordination. The objectives of this paper are to: report and review various perspectives on SC coordination issues, understand and appreciate various mechanisms available for coordination and identify the gaps existing in the literature. A framework is suggested indicating scope for further research.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
La crise sanitaire a intensifié le contrôle des circulations humaines. Les efforts de coordination des instances multilatérales se sont heurtés à la souveraineté des Etats dans les domaines de la ...santé et des migrations.
While medicinal inorganic chemistry has been practised for over 5000 years, it was not until the late 1800s when Alfred Werner published his ground-breaking research on coordination chemistry that we ...began to truly understand the nature of the coordination bond and the structures and stereochemistries of metal complexes. We can now readily manipulate and fine-tune their properties. This had led to a multitude of complexes with wide-ranging biomedical applications. This review will focus on the use and potential of metal complexes as important therapeutic agents for the treatment of cancer. With major advances in technologies and a deeper understanding of the human genome, we are now in a strong position to more fully understand carcinogenesis at a molecular level. We can now also rationally design and develop drug molecules that can either selectively enhance or disrupt key biological processes and, in doing so, optimize their therapeutic potential. This has heralded a new era in drug design in which we are moving from a single- toward a multitargeted approach. This approach lies at the very heart of medicinal inorganic chemistry. In this review, we have endeavored to showcase how a “multitargeted” approach to drug design has led to new families of metallodrugs which may not only reduce systemic toxicities associated with modern day chemotherapeutics but also address resistance issues that are plaguing many chemotherapeutic regimens. We have focused our attention on metallodrugs incorporating platinum and ruthenium ions given that complexes containing these metal ions are already in clinical use or have advanced to clinical trials as anticancer agents. The “multitargeted” complexes described herein not only target DNA but also contain either vectors to enable them to target cancer cells selectively and/or moieties that target enzymes, peptides, and intracellular proteins. Multitargeted complexes which have been designed to target the mitochondria or complexes inspired by natural product activity are also described. A summary of advances in this field over the past decade or so will be provided.
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IJS, KILJ, NUK, PNG, UL, UM
Noëlle Lasne est médecin généraliste. Après avoir exercé en cabinet de ville, elle a, en 1990, rejoint la mission France de Médecins Sans Frontières dont la création représentait un tournant majeur ...dans les activités de l’ONG humanitaire internationale. Il s’agissait d’un retour « à domicile » motivé par la multiplication des situations de non-accès aux soins que ce soit pour les étranger.ères sans-papiers, les travailleur.euses en fin de droits ou les victimes des nouvelles formes de précarité. Elle en a assuré la coordination tout au long des années 1990 alors que le travail de soin de la mission était en prise directe sur les initiatives et mobilisations qui aboutirent à la création de la Couverture Maladie Universelle et de l’Aide Médicale d’État pour les étrangers sans-papiers. Elle revient pour Mouvements sur cette expérience.
Due to the increasing impact of cancer on worldwide mortality, more and more attention is being devoted to the investigation of novel anticancer strategies. Among these, chemotherapy plays a key role ...in fighting cancer. This explains the increasing engagement of both the pharmaceutical industry and academia towards the discovery of new chemotherapeutic agents. In recent years, metal-based drugs have attracted much attention due to their atypical physico-chemical properties compared to organic molecules. After the approval of cisplatin as a chemotherapeutic agent in 1978, several types of metal-based drugs have been explored. Among them, Ru-based anticancer drug candidates have become a central subject in this research field. However, most of the Ru-based compounds investigated over the last two decades express their cytotoxicity with a mechanism of action involving, among others, a ligand-exchange mechanism. In this Review, we give a complete overview of a specific class of antiproliferative ruthenium complexes, namely coordinatively saturated and substitutionally inert Ru(
ii
) polypyridyl complexes. This implies that the cytotoxicity observed comes from the entire complex and not from ligand-exchange. In this Review, we present monomeric and dimeric Ru(
ii
) polypyridyl complexes, which have been found to be toxic to cancer cells. More specifically, monomeric Ru(
ii
) polypyridyl complexes are analysed considering their direct interaction or not with DNA as the cause of cell death, while dimeric Ru(
ii
) polypyridyl complexes are classified according to their biological targets. Very importantly, the cellular targets of these complexes are discussed in detail. Indeed, several targets were identified and different mechanisms of action were suggested.
Monomeric and dimeric coordinatively saturated and substitutionally inert Ru(
ii
) polypyridyl complexes with anticancer properties are reviewed.
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