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The myth of autoimmunity Monif, Gilles R.G.
Medical hypotheses,
December 2018, 2018-Dec, 2018-12-00, 20181201, Volume:
121
Journal Article
Peer reviewed
Within the more than one hundred disease entities for which autoimmunity causation have been alleged, two subgroups can be identified. The first group is characterized by ability of disruption of the ...effector arm of the immune response to temporarily reverse the signs and symptoms of disease. The second group is characterized by the presence of antibodies directed against the target organ’s cellular or subcellular components. As long as therapeutic palliation of the signs and symptoms of disease can be achieved, attributing causation to autoimmunity has tended to arrest therapeutics focus on attaining cure. Data relevant to a prime disease entity within each of the two allegedly autoimmune disease, Crohn’s disease and Type 1 diabetes mellitus, refute the claim of autoimmunity. In particular, the events that combine to produce Crohn’s disease have identified a mechanism by which a dysfunctional immune-mediated response against a specific set of antigens/agent can produces disease. Identification of this mechanism opens to rethinking the pathogenesis of other classic autoimmune diseases within that 5 subgroup.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Infectious Diseases Incorporated (IDI) is an infectious disease think-tank, established in 1973. Crohn’s disease (CD) is a chronic, recurrent disease of the gastrointestinal tract that has reached ...epidemic proportions within industrialized nations. CD is said to be without cure. Since 2003, therapeutic interventions have focused on disruption of the pro-inflammatory Th1 response against an unknown antigen. In 2015, the Hruska Postulate was introduced and, in so doing, explained how, in the absence of acquired immunity, newborn infection by Mycobacterium avium subspecies paratuberculosis could cause fixation of the immune system’s Th1 response against the organism. The Hruska Postulate was utilized to answer all the documented epidemiological facts embedded in the natural history of Crohn’s disease and, in particular, why breastfeeding confers protection against the future development of Crohn’s disease. It is Infectious Diseases Incorporated’s (IDI) stated opinion that Crohn’s disease is both preventable and curable if treated appropriately in its early stages.
IN MEMORY: ARTURO HRUSKA Marzaduri, Eleonora
The Journal of oral implantology,
03/2006, Volume:
32, Issue:
2
Journal Article
Peer reviewed
Marzaduri presents an obituary for Dr Arturo Hruska, a long-time Fellow and Honored Fellow of the American Academy of Implant Dentistry. Among his greatest achievements were his engineering ...capabilities. He was the recipient of nine international patents awarded for his famous intraoral welding machine and for a decontamination device applicable to titanium castings. These inventions permitted the widespread techniques of using cast titanium for restorative prostheses.
Bradley J Hruska in the November 2011 issue of Update: Applications of Research in Music Education writes that there is perhaps no larger influence on student achievement today than motivation. In ...his article, Hruska offers research-based suggestions for high school music teachers to help them encourage their students to become more motivated through mastery learning goals. The piece also explores how student leadership opportunities can promote mastery learning.
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BFBNIB, DOBA, IZUM, KILJ, NMLJ, NUK, OILJ, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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