•Two contained multinuclear Cu clusters POM-based inorganic-organic hybrid compounds are designed and prepared.•Cu-SiMo exhibits a unique sandwich type three-dimensional supramolecular framework ...structure through hydrogen bonding interactions between trinuclear Cu and SiMo12 POMs.•Cu-SiMo exhibits an excellent capacitance of 992 F g–1 at 2 A g−1.•The Cu-SiMo electrode only experienced a capacitance loss of 2.31 % and columbic efficiency loss of 1 % after 1000 cycles at a high charge/discharge current density of 20 A g–1.
Polyoxometalates (POMs) have used as advanced energy storage materials due to their unique structures, and highly stable redox stability. By adjusting the type of POMs, two Cu-based POMs compounds, formulated as {Cu(HL)2(L)2(H2O)2(HL)2(NaMo8O26)2}·2H2O} (Cu-Mo8), {Cu(L)2(H2O)2(SiMo12O40)(Cu3(μ-OH)(L)4(H2O)2(SiMo12O40)2·12H2O} (Cu-SiMo) (L = 1-methyl-thiophene-pyridine) are synthesized and directly used as electrode materials for supercapacitors. Cu-Mo8 contains a one-dimensional inorganic chain of Na-Mo8Na by using Na as the connecting point. For Cu-SiMo, the SiMo POMs are connected with Cu(II) and form a one-dimensional (1D) chain. And it exhibits a unique two-dimensional and three-dimensional supramolecular framework structure connected by hydrogen bonds between trinuclear Cu and SiMo12 POMs. Benefiting from the 1D chain of mononuclear Cu and stable trinuclear coordinated Cu structure, and 3D supramolecular framework through the intermolecular hydrogen bond, Cu-SiMo exhibits the higher linear capacitance (992 F g–1 at 2 A g–1), stability (97.69 %) and columbic efficiency (99 %) after 1000 cycles, which is better than general of the reported POM-based electrodes materials.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
A surface corona of curcumin and isonicotinic acid hydrazide is developed on gold nanoparticles for improved anticancer activity. The selective toxicity of functional nanoparticles is shown on human ...lung squamous carcinoma, and cytocompatibility towards human lung fibroblasts.
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•A new approach to improve potential of gold nanoparticles is demonstrated by developing a suitable surface corona.•The curcumin and isonicotinic acid hydrazide formed a functional corona on gold nanoparticles for anticancer action.•Investigations on human lung squamous carcinoma and human lung fibroblasts indicate selective toxicity.•The work reveals that facile surfaces on nanoparticles are important in controlling bio-medical potential of nanoparticles.
Besides physicochemical properties, careful design of biomolecular surface corona can dictate therapeutic potential of nanoparticles. Therefore, we demonstrate a new approach to improve the anticancer potential of gold nanoparticles (AuNPs) by developing a strong corona of curcumin and isonicotinic acid hydrazide (INH) around them. Here, curcumin reduced AuNPsCur are surface-functionalized with biologically active INH (AuNPsCur@INH). Our investigations on human lung squamous carcinoma (LK-2) and human lung fibroblast (TIG-120) cells indicate selective toxicity of functionalized nanoparticles. Conjugation of curcumin and INH on the surface of AuNPs induced anticancer action through reactive oxygen species (ROS) generation. The further extension of this study revealed apoptosis and morphological changes in LK-2 and TIG-120 cells, respectively. Moreover, the anticancer potential of these nanoparticles is compared with standard cisplatin. The outcomes of the work determine that the facile functional surfaces on nanoparticles can be important in controlling the biological activities of nanoparticles.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The increased biomedical applications of enzyme-mimicking nanoparticles, also known as ‘nanozymes’ has necessitated their controlled design in terms of physicochemical properties, and reduced ...toxicity. In this context, numerous approaches have been established to manufacture nanozymes using eco-friendly routes, however, controlled surfaces and suitable functionalization of nanozymes need much attention to utilize their full potential. Here, serine synthesised silver (Ag) nanozymes have been fabricated, and sequentially surface functionalized with isonicotinic acid hydrazide (isoniazid), streptomycin, and phosphomolybdic acid to control their nanozyme-mimicking nature, and impart biological capabilities. Post-physicochemical characterization, all these functional Ag-centred nanozymes were explored for their inherent peroxidase enzyme-like behavior, and haemcompatibility. The cell viability and proliferation assessments towards mouse RAW 264.7 macrophages confirmed the cytocompatible nature of Ag nanozymes. Moreover, these nanozymes show anti-inflammatory potential by regulating the key inflammatory cytokines IL-6, IL-β, and TNF-α.
The serine-capped silver nanozymes have been engineered, and modified with isonicotinic acid hydrazide, streptomycin, and phosphomolybdic acid to enrich their biological applicability. The functional nanozymes show in vitro peroxidase-mimicking behaviour, haem- and cyto-compatibility. Moreover, these nanozymes down-regulate the expression of pro-inflammatory IL-6, IL-β, and TNF-α by governing the cytokine homeostasis in mouse macrophages. Display omitted
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Nano-sized electrodes have their special advantages for sensing applications, such as small overall dimension, fast response and low background current. In this work, single gold nanoclusters (AuNCs) ...were controllably prepared on single Pt nanoelectrode surface by electrodeposition method. The AuNCs covered Pt nanoelectrode (AuNCs/PtNE) had steady-state voltammetric response in redox species solution, which was similar to micro-/nano-sized electrodes. It was interesting to find isonicotinic acid hydrazide (INH, also known as isoniazid) showed good electrochemical response on AuNCs/PtNE surface, which had investigated carefully by square wave voltammetry (SWV) and chronoamperometry. Moreover, the prepared single AuNCs/PtNEs showed the capability for INH sensing with good sensitivity, reproducibility and selectivity, which was demonstrated for INH detection in human urine samples.
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•Single gold nanoclusters (AuNCs) were controllably prepared on single Pt nanoelectrode surface by electrodeposition method.•The single AuNCs/PtNE showed excellent electrochemical responses for isonicotinic acid hydrazide (INH) oxidation.•A single AuNCs-based nanosensor was developed for INH sensing with good sensitivity, reproducibility and selectivity.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Decades of nanomedicine research has demonstrated the importance of physicochemical properties to tightly regulate cytotoxicity of nanoparticles. Wherein, the tailor-made surface corona of ...nanoparticles may dictate nano-bio interfacial interactions toward therapeutic benefits without any significant nanotoxicity. Therefore, in the current research, selective anticancer effects originating from the specific surface chemistry of silver nanoparticles (AgNPs) is demonstrated employing lung cells. The AgNPs are synthesized by bioactive curcumin (Cur) to form a stable corona around AgNPs, and further surface functionalized with an antibiotic isonicotinic acid hydrazide (INH, isoniazid). These NPs were subjected to various structural and spectroscopy analysis for deeper understanding of the surface chemistry, followed by the anticancer potential assessment on LK-2 lung cancer cells. The higher production of reactive oxygen species (ROS) was responsible for therapeutic effects on LK-2 cells. The TUNEL and apoptotic dye studies revealed and confirmed the role of apoptosis in the ROS-mediated selective death of lung cancer cells over human foetus lung diploid fibroblasts (WI-38). Furthermore, the involvement of mitochondria in mediating the effects of AgNP's toxicity is demonstrated. The study provides a deeper understanding regarding the mechanism of anti-cancer actions of the formulated functional AgNPs, and it has potential to open new avenues for tailor-made surfaces chemistry driven nanomedicine development.
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•Curcumin and isonicotinic acid hydrazide surface functionalized silver (Ag) nanoparticles are synthesized.•Functional Ag nanoparticles exhibit anticancer potential by apoptosis, and antioxidant ability toward fibroblasts.•Involvement of mitochondria in exerting ROS-mediated apoptosis is revealed for enhanced anti-cancerous efficacy.•The study has potential to open new avenues for tailor-made surface chemistry driven nanomedicine development.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
•A series of new Scaffold isonicotinoyl-pyrazolyl-coumarin dyads was synthesized.•The structures of the new hybrid compounds were performed by spectroscopic means.•All the compounds were screened ...in vitro for their potential Antifungal and Antioxidant activities.•Theoretical calculations were done for the molecules geometries.•Synthesized compounds were docked with fungal protein (Phytase A) from Aspergillus niger using AutoDock 4 software
A new series of 3-(5-Hydroxy-1-isonicotinoyl-3-methyl-4,5-dihydro-1H-pyrazol-5-yl)-2H-chromen-2-one derivatives 3a-g was efficiently synthesized under environmentally friendly reaction conditions by reaction of 3-acetoacetylcoumarin derivatives 1a-g with isoniazid 2. The reaction is conveniently performed at room temperature using Knorr pyrazole syntheses. The key features of this approach are its operational simplicity, the facile access to the desired products, and the good to excellent yields. The structures of the newly synthesized compounds were established by 1H, 13C, 2D NMR spectroscopy and mass spectrometry. 1H-15N HMBC experiments were also conducted to assess the regiochemistry of final compounds. All the synthesized compounds were evaluated for their in vitro antifungal activity against both Candida albicans and Aspergillus niger strains and compared to the standard drug Ketoconazole. Among all the compounds, 3d and 3e were the most effective, showing high potential antigungal inhibitory activities with respective MIC values of 15.62 µg ml−1 for 3e against Aspergillus niger. All the newly synthesized derivatives 3a-g are evaluated for their antioxidant activity and showed good activity. SAR studies demonstrated that the presence of nitro and hydroxyl groups in the aromatic ring of the coumarin and pyrazoline rings conferred enhanced antioxidant and antifungal activity. In addition, molecular docking studies were performed for compound 3e to evaluate its potential as an inhibitor of the fungal protein (Phytase A) from Aspergillus niger and the results suggested that our isonicotinoyl-pyrazolyl-coumarin may act as promising antifungal agent.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The electroactive composites based on reduced graphene oxide (RGO), poly‐o‐phenylenediamine (PPD) and heteropolyacids – H4SiW12O40nH2O (SiW) and H3PW12O40 ⋅ nH2O (PW) was applied to a screen‐printed ...carbon electrode (SPCE) as a planar three‐electrode cell as the first step to creating various devices, in particular, sensors and catalysts. We studied potential use of the modified and unmodified SPCE planar electrode in determining the concentration of antitubercular antibiotic isoniazid (isonicotinic acid hydrazide C6H7N3O or INH). The best result was observed for SPCE+RGO‐PPD‐SiW. CV of normal saline with various concentrations of C6H7N3O demonstrated linear dependence of the relevant anodic peak current either in the bulk solution upon immersion of the modified electrode or in a droplet on the electrode surface.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Luminescent complexes illustrate high interest as luminescent materials in the fields of optical communications, lighting, sensors and biomedical devices. This review gives the structural and ...luminescent studies on isonicotinic acid based complexes, and probably provides the structure-property relationship. These complexes display various luminescent properties, such as luminescent probe, different luminescence when immersed in different organic solvents. This review is divided into three sections to discuss, including transition-metal, lanthanide, lanthanide-transition heterometal. The approach will help design and synthesis of luminescent complexes as promising materials.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Nano‐scaled coordination complexes (CC) exhibiting the structures Ag (INH)2.OH.H2O (CC1), Ni(4,4′‐bpy)(H2O)4(4‐aba)2.4H2O (CC2), (INH = isonicotinic acid, 4,4′‐bpy = 4,4′‐bipyridine, 4‐aba ...= aminobenzoate) were prepared via self‐assembly and sono‐chemical methods at ambient conditions. The structures were fully studied by single‐crystal XRD and analytical investigations. Water molecules and the hydroxyl ions act as guests connecting the discrete molecules in complex 1, whereas in 2 the coordinate water molecules form the 1D chains of Ni(4,4′‐bpy)(H2O)4 which are H‐bonded to the guest H2O molecules and aminobenzoate anions. The structures of CC 1 and 2 are stabilized into 3D‐supramolecular topology through H bonds and π–π stacking interactions. The nanosized tested compounds 1\ and 2\ are designed to investigate their action on viability and proliferation of five human cancer cell lines. In addition, ABTS assay and rate erythrocyte hemolysis were used to test the antioxidant activity of the nanosized 1\ and 2\. Also, the coordination complexes 1\ and 2\ exhibit good antimicrobial activity keeping them as promising drug candidates for the treatment of bacterial and fungal infections.
Nano‐scaled coordination complexes (CC) exhibiting the structures Ag (INH)2 .OH.H2O (CC1), Ni(4,4′‐bpy)(H2O)4 (4‐aba)2.4H2O (CC2) were prepared via self‐assembly and sono‐chemical methods. Water molecules and the hydroxyl ions act as guests connecting the discrete molecules in complex 1, whereas in 2 the coordinate water molecules form the 1D chains of Ni(4,4′‐bpy)(H2O)4 which are H‐bonded to the guest H2O molecules and aminobenzoate anions. The TEM images of 1\ and 2\ exhibit regular nanostructures and narrower morphology. 1\ and 2\ exhibit good anti‐hemolytic and antimicrobial activities.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
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