This book explores the links among ecology, disease, and international politics in the context of the Greater Caribbean - the landscapes lying between Surinam and the Chesapeake - in the seventeenth ...through early twentieth centuries. Ecological changes made these landscapes especially suitable for the vector mosquitoes of yellow fever and malaria, and these diseases wrought systematic havoc among armies and would-be settlers. Because yellow fever confers immunity on survivors of the disease, and because malaria confers resistance, these diseases played partisan roles in the struggles for empire and revolution, attacking some populations more severely than others. In particular, yellow fever and malaria attacked newcomers to the region, which helped keep the Spanish Empire Spanish in the face of predatory rivals in the seventeenth and early eighteenth centuries. In the late eighteenth and through the nineteenth century, these diseases helped revolutions to succeed by decimating forces sent out from Europe to prevent them.
Among the most far-reaching effects of the modern environmental movement was the widespread acknowledgment that human beings were inescapably part of a larger ecosystem. With this book, Linda Nash ...gives us a wholly original and much longer history of "ecological" ideas of the body as that history unfolded in California's Central Valley. Taking us from nineteenth-century fears of miasmas and faith in wilderness cures to the recent era of chemical pollution and cancer clusters, Nash charts how Americans have connected their diseases to race and place as well as dirt and germs. In this account, the rise of germ theory and the pushing aside of an earlier environmental approach to illness constituted not a clear triumph of modern biomedicine but rather a brief period of modern amnesia. As Nash shows us, place-based accounts of illness re-emerged in the postwar decades, galvanizing environmental protest against smog and toxic chemicals. Carefully researched and richly conceptual,Inescapable Ecologiesbrings critically important insights to the histories of environment, culture, and public health, while offering a provocative commentary on the human relationship to the larger world.
The aim: to study the permanent risk factor of oncopathology in order to determine its medical and geographical features and assess their impact on oncopathology of the population of Zaporizhzhia ...region.
Materials and methods. By means of spatial and geographical, as well as analytical and statistical methods, territories were medically and statistically differentiated, with the assessment of the natural environment quality. Epidemiological study of malignant neoplasms was conducted retrospectively for the period of 2004–2015, in accordance with the International Classification of Diseases ICD-10. Determination of environmental impact on oncopathology was performed using the attributive fraction.
Results. Geoactive space is characterized by a variety of natural and climatic conditions of lithosphere, hydrosphere and landscapes. The main physical and geographical objects of the Zaporizhzhia region (Ukrainian Crystal Shield, the Dnipro, the Sea of Azov) form six zones, which differ in the diversity of system-forming elements. Specific features of discontinuous disturbances of the lithosphere of the Ukrainian crystal shield are abnormally high electrical conductivity of the earth’s crust, intense electromagnetic fields, high concentration of radon in aquifers, and streams of high-energy fluids.
Conclusions. The highest geopathogenic impact is manifested in the fault zone of the Ukrainian crystal shield. The highest values of the attributive fraction of malignant neoplasms were registered in this zone among the whole population (26.8 %), among the adult population (25.4 %) and the able-bodied population (32.7 %). The oncopathological potential of natural conditions was least manifested in the valley of the Dnipro breakthrough and the Azov Upland, where the attributive fraction for almost all indicators did not exceed 8.2 %.
The cholera epidemics that plagued London in the nineteenth century were a turning point in the science of epidemiology and public health, and the use of maps to pinpoint the source of the disease ...initiated an explosion of medical and social mapping not only in London but throughout the British Empire as well. Mapping the Victorian Social Body explores the impact of such maps on Victorian and, ultimately, present-day perceptions of space. Tracing the development of cholera mapping from the early sanitary period to the later “medical” period of which John Snow’s work was a key example, the book explores how maps of cholera outbreaks, residents’ responses to those maps, and the novels of Charles Dickens, who drew heavily on this material, contributed to an emerging vision of London as a metropolis. The book then turns to India, the metropole’s colonial other and the perceived source of the disease. In India, the book argues, imperial politics took cholera mapping in a wholly different direction and contributed to Britons’ perceptions of Indian space as quite different from that of home. The book concludes by tracing the persistence of Victorian themes in current discourse, particularly in terms of the identification of large cities with cancerous growth and of Africa with AIDS.
This book provides an overview of the use of spatial statistics in epidemiology — the study of the incidence and distribution of diseases. Used appropriately, spatial analytical methods in ...conjunction with GIS and remotely sensed data can provide significant insights into the biological patterns and processes that underlie disease transmission. In turn, these can be used to understand and predict disease prevalence. This book brings together the specialised and widely-dispersed literature on spatial analysis to make these methodological tools accessible to epidemiologists for the first time. With its focus on application rather than theory, this book includes examples taken from both medical (human) and veterinary (animal) disciplines, and describes both infectious diseases and non-infectious conditions. It also provides worked examples of methodologies using a single data set from the same disease example throughout, and is structured to follow the logical sequence of description of spatial data, visualisation, exploration, modelling, and decision support.
Dysbiosis, departure of the gut microbiome from a healthy state, has been suggested to be a powerful biomarker of disease incidence and progression
. Diagnostic applications have been proposed for ...inflammatory bowel disease diagnosis and prognosis
, colorectal cancer prescreening
and therapeutic choices in melanoma
. Noninvasive sampling could facilitate large-scale public health applications, including early diagnosis and risk assessment in metabolic
and cardiovascular diseases
. To understand the generalizability of microbiota-based diagnostic models of metabolic disease, we characterized the gut microbiota of 7,009 individuals from 14 districts within 1 province in China. Among phenotypes, host location showed the strongest associations with microbiota variations. Microbiota-based metabolic disease models developed in one location failed when used elsewhere, suggesting that such models cannot be extrapolated. Interpolated models performed much better, especially in diseases with obvious microbiota-related characteristics. Interpolation efficiency decreased as geographic scale increased, indicating a need to build localized baseline and disease models to predict metabolic risks.
NAFLD is a clinical syndrome characterized by predominant macrovesicular steatosis of the liver. The clinical and histological phenotypes of NAFLD extend from a nonalcoholic fatty liver to NASH. ...Although the prevalence of NAFLD is increasing globally, and it is set to become the predominant cause of chronic liver disease in many parts of the world, the epidemiology and demographic characteristics of NAFLD vary worldwide. Indeed, the condition is associated with obesity and insulin resistance in most cases in the Western world, but the disease manifests at a lower BMI in Asian countries and many patients do not seem to have insulin resistance as determined using conventional methods. The similarities and differences in the epidemiology of NAFLD in different regions of the world are discussed and the potential role of genetics and insulin resistance in disease progression is also presented.
Rabies is a notoriously underreported and neglected disease of low-income countries. This study aims to estimate the public health and economic burden of rabies circulating in domestic dog ...populations, globally and on a country-by-country basis, allowing an objective assessment of how much this preventable disease costs endemic countries.
We established relationships between rabies mortality and rabies prevention and control measures, which we incorporated into a model framework. We used data derived from extensive literature searches and questionnaires on disease incidence, control interventions and preventative measures within this framework to estimate the disease burden. The burden of rabies impacts on public health sector budgets, local communities and livestock economies, with the highest risk of rabies in the poorest regions of the world. This study estimates that globally canine rabies causes approximately 59,000 (95% Confidence Intervals: 25-159,000) human deaths, over 3.7 million (95% CIs: 1.6-10.4 million) disability-adjusted life years (DALYs) and 8.6 billion USD (95% CIs: 2.9-21.5 billion) economic losses annually. The largest component of the economic burden is due to premature death (55%), followed by direct costs of post-exposure prophylaxis (PEP, 20%) and lost income whilst seeking PEP (15.5%), with only limited costs to the veterinary sector due to dog vaccination (1.5%), and additional costs to communities from livestock losses (6%).
This study demonstrates that investment in dog vaccination, the single most effective way of reducing the disease burden, has been inadequate and that the availability and affordability of PEP needs improving. Collaborative investments by medical and veterinary sectors could dramatically reduce the current large, and unnecessary, burden of rabies on affected communities. Improved surveillance is needed to reduce uncertainty in burden estimates and to monitor the impacts of control efforts.
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