Incorporation of curcumin (Cur) into a hydrogel system is an interesting approach to treat full-thickness skin wounds because Cur can potentiate healing by affecting different stages of the wound ...healing. Due to its hydrophobicity, Cur solubilization is a great challenge. Thus, Cur solubilization by pluronic F-127, gelation capacity of polyvinyl alcohol (PVA) and porosity enhancement by TEMPO-oxidized cellulose nanofiber (TOCN) can inaugurate a biocompatible and biodegradable hydrogel system for Cur delivery. In this study, a Cur incorporated physically crosslinked TOCN-PVA-Cur hydrogel was prepared by a freeze-thaw process, which released Cur to accelerate wound healing. The viscosity of the hydrogel was increased by increasing the PVA concentration. In vitro studies revealed that, L929 fibroblast cells internalized curcumin within 4 h of incubation. After the application of the TOCN-PVA-Cur into rat full-thickness skin wounds, the percentage of wound closures was increased compared to that in the control group. Distinct neoepidermise and granulation tissue formed in hydrogel treated groups and collagen fibers accumulated near defect areas at the two weeks after treatment. These results showed show that the delivery of curcumin by TOCN-PVA-Cur hydrogel can be an effective method for promoting natural wound healing processes.
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•Curcumin incorporated into oxidized cellulose-polyvinyl alcohol hydrogel system by freeze-thawing process.•Desired viscosity ensures injectibility of hydrogel.•L929 fibroblast cells uptake curcumin-pluronic micelle when released from hydrogel system.•Curcumin incorporation accelerates full-thickness skin wound healing.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The interface plays a pivotal role in stabilizing metal anode. Extensive studies have been made but systematic research is lacking. In this study, preliminary studies are conducted to explore the ...prime conditions of interfacial modification to approach the practical requirements. Critical factors including reaction kinetics, transport rate, and modulus are identified to affect the Zn anode morphology significantly. The fundamental principle to enhance the Zn anode stability is systematically studied using the TEMPO‐oxidized cellulose nanofiber (TOCNF) coating layer with thin a separator. Its advantageous mechanical properties buffer the huge volume variation. The existence of hydrophilic TOCNF in the Zn anode interface enhances the mass transfer process and alters the Zn2+ distribution with a record high double‐layer capacitance (390 uF cm−2). With the synergetic effect, the modified Zn anode works stably under 5 mA cm−2 with a thin nonwoven paper as the separator (thickness 113 µm). At an ultra‐high current density of 10 mA cm−2, this coated anode cycles for more than 300 h. This strategy shows an immense potential to drive the Zn anode forward toward practical applications.
In this study, reaction kinetics, transport rate, and modulus are identified as critical factors that affect the Zn anode stability. Further, the TEMPO‐oxidized cellulose nanofiber (TOCNF) coating layer with high mechanical strength and abundant carboxylate groups is demonstrated to enhance the mass transfer kinetics and altered the Zn2+ distribution, stabilizing the Zn anode.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
•An effective pineapple leaf pulp extraction with a cellulose content of 91.66%.•TEMPO-oxidized pulp/chitosan aerogels prepared by self-crosslinking.•The ultra-lightweight composite aerogel shows a ...density of 8.46 mg/cm3 and porosity of 99.36%.•An exponential increase in Young’s modulus of composite aerogels reinforced by chitosan.•The methyl orange adsorption uptake of 136.64 mg/g in 6 min by hybrid aerogels.
Recycling agricultural and aquacultural by-products into high-value engineering aerogels is a sustainable solution to minimize the negative impacts of these wastes on the environment in case of improper treatment. For the first time, discarded pineapple leaves are processed by a novel two-step procedure involving strong alkali and alkali/hydrogen peroxide treatments to generate cellulose-rich pulp containing 91.66 wt% cellulose. The mediated oxidation catalyzed by 2,2,6,6-tetramethylpiperidinyloxy is performed to introduce more carboxylate groups in the pulp for further physically interacting with amino groups on shrimp-based chitosan to synthesize unique composite aerogels without consuming any crosslinkers. The composite aerogels are ultra-lightweight and exhibit a significant rise in their compressive modulus from 2.46 to 27.25 kPa due to the chitosan addition. At the same initial dye concentration of 300 mg/L, the composite aerogels composed of 0.6 wt% chitosan achieve the equilibrium methyl orange adsorption capacity of 136.64 mg/g in only 6 min, while the highest equilibrium methylene blue adsorption uptake of 31.56 mg/g is witnessed in the samples having the lowest chitosan content (0.2 wt%). The developed composite aerogels display the notable porous structure, remarkable mechanical properties, and high removal efficiency for the two typical dyes, demonstrating the effectiveness of combining the world’s two largest natural sources by a simple and green fabrication. The approach in this study is directed towards multiple goals such as addressing the accumulation and underutilization of solid waste, dealing with water pollution caused by harmful dyes in many developing countries, and providing another solution for the cleaner production of renewable materials.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
•The oxidation, origin, and biodegradability of oxidized cellulose are reported.•The application of oxidized cellulose for hemostatic materials is described.•Various forms of oxidized cellulose-based ...hemostatic materials are discussed.•Modification of oxidized cellulose-based hemostatic materials is introduced.
The application of hemostatic agents is essential to prevent significant blood loss and death from excessive bleeding in surgical or emergency scenarios. Oxidized cellulose is an excellent biodegradable and biocompatible derivate of cellulose, which has become one of the most important hemostatic agents used in surgical procedures. However, to date, there has been no comprehensive report assessing oxidized cellulose-based hemostatic materials. Hence, this paper first reviewed the oxidation preparation, cellulose origin and structure, as well as biodegradability and safety of oxidized cellulose. Then a comprehensive review regarding the hemostatic mechanisms, various forms, modification, and current commercially available products of oxidized cellulose is discussed, which emphatically presents the most significant developments in the recent scientific literature. In conclusion, this paper summarizes the latest developments in oxidized cellulose-based hemostatic materials and provides a reference for further research and development in this field.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
•Developed cellulosic-based electrochemical sensor for tetracycline detection.•Innovative use of SWCNTs and TOCNF-PEI hybrids in sensor architecture.•Effective in detecting tetracycline in both PBS ...and wastewater effluent.•Compatible with large-scale production for green, versatile sensing devices.
Antibiotics play a pivotal role in healthcare and agriculture, but their overuse and environmental presence pose critical challenges. Developing sustainable and effective detection methodologies is crucial to mitigating antibiotic resistance and environmental contamination. This study presents a cellulosic polymer-based electrochemical sensor by integrating TEMPO-oxidized cellulose nanofibers-polyethyleneimine hybrids (TOCNFs-PEI) with single-walled carbon nanotube networks (SWCNTs). Our research focuses on (i) conducting physicochemical and electrochemical studies of multifunctional SWCNT/TOCNFs-PEI architectures, (ii) elucidating the relationships between the material's properties and their electrochemical performance, and (iii) assessing its performance in detecting tetracycline concentrations in both controlled and more complex matrices (treated wastewater effluents). The limits of detection were evaluated to be 0.180 µmol L−1 (at the potential of 0.85 V) and 0.112 µmol L−1 (at the potential of 0.65 V) in phosphate-buffered saline solution, and 2.46 µmol L−1 (at the potential of 0.82 V) and 1.5 µmol L−1 (at the potential of 0.65 V) in the undiluted membrane bioreactor effluent sample, respectively. Further, the designed cellulosic polymer-based sensing architecture is compatible with large-scale production, paving the way for a new era of green, versatile sensing devices. These developments will significantly contribute to global efforts to alleviate antibiotic resistance and environmental contamination.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
•Oxidized cellulose nanocrystals (CNCs) were prepared using ammonium persulfate method.•Cotton linter (CL) and microcrystalline cellulose (MCC) were used as cellulose sources.•The CNCs were used as ...reinforcing filler for preparation of CMC-based nanocomposite films.•CNCCL exhibited higher crystallinity, mechanical strength, and transparency than CNCMCC.
Cellulose nanocrystals (CNCs) were isolated from cotton linter (CL) and microcrystalline cellulose (MCC) using an ammonium persulfate (APS) method for a simultaneous isolation and oxidation of CNCs. The CNCs were in rod-like shape with a diameter of 10.3nm and 11.4nm, a length of 120–150nm and 103–337nm, a crystallinity index of 93.5% and 79.1% for the CNCCL and CNCMCC, respectively. The suspensions of oxidized CNCs were transparent and stable with the zeta potential values of −50.6mV and −46.9mV. The CNCs were uniformly distributed within the carboxymethyl cellulose (CMC) polymer matrix. The tensile strength (TS) increased by 102% and 73%, and elastic modulus (E) increased by 228% and 166% with the incorporation of at 10wt% of CNCCL and CNCMCC, respectively. Conclusively, the CNCCL showed a more uniform particle size distribution, higher crystallinity, transparency, thermal stability, and superior mechanical strength compared with the CNCMCC.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
The three-dimensional (3D) printed scaffolds were prepared by partial cross-linking of TEMPO-oxidized cellulose nanofibril/alginate hydrogel using calcium ions for printing the hydrogel while ...maintaining its shape, fidelity, and preventing the collapse of the filaments. The prepared scaffolds were fully cross-linked using calcium ions immediately after printing to provide the rigidity of the hydrogel and give it long-term stability. The composition of the prepared pastes was adjusted in view of the description of the hydrogel and 3D printing parameters. The rheological properties in terms of thixotropic behavior and viscosity recovery of hydrogels were investigated by performing steady shear rate experiments. The results show that the viscosity recovery for pure alginate hydrogel was only about 16% of the initial value, whereas it was 66% when adding cellulose nanofibrils to alginate. Consequently, the shape of the pure alginate scaffold was soft and easy to collapse contrarily to the composite scaffold. The biomimetic mineralization process of printed scaffolds using simulated body fluid, mimicking the inorganic composition of human blood plasma, was performed and the hydroxyapatite nucleation on the hydrogel was confirmed. The strength properties of the fabricated scaffolds in terms of compressive strength analysis were also investigated and discussed. The results show that the alginate/TEMPO-oxidized cellulose nanofibril system may be a promising 3D printing scaffold for bone tissue engineering.
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IJS, KILJ, NUK, PNG, UL, UM
Remaining Surgicel in the body can be mistaken for complications such as hematoma, abscess, or tumor recurrence in paraclinical examinations after surgery. We have presented the case of kidney cancer ...who underwent radical nephrectomy. In radiological follow-ups, hematoma was reported in the surgery site. The typical appearance of Surgicel on a postoperative CT scan is characterized by air trapped bubbles. Surgicel exhibits a short relaxation time on T2-weighted images. It is important to differentiate the remaining Surgicel from cases such as hematoma, abscess and tumor recurrence. T2MRI images will be most accurate in the correct diagnosis of Surgicel.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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•A facile and lyophilization-free method to fabricate anisotropic cellulose aerogels.•Directional stabilization of cellulose nanofibrils induced by electrostatic ...complexation.•Ambient-dried cellulose aerogels have porous structure and aligned channels.•NCA@PPy achieves excellent photothermal property and efficient solar evaporation.
Anisotropic aerogels, mimicking natural porous materials such as wood and bone, always exhibit distinctive properties due to their aligned channels, which, however, generally require complicated ice templating configuration and costly freeze-drying. In this work, we develop a novel, facile, low-cost, and scalable method combining directional stabilization and ambient drying to prepare anisotropic aerogels. The frozen aqueous TEMPO-oxidized cellulose nanofibrils (TOCNFs) monolith embedded in a mold is directly immersed in ethanol/Fe3+ bath. The ice crystals directionally dissolve in ethanol, and simultaneously the TOCNFs are directionally stabilized due to the electrostatic complexation between their carboxyl groups and Fe3+ ions. The obtained anisotropic nanocellulose aerogel (NCA) after ambient drying exhibits an ordered porous structure, which is tunable by adjusting the contents of carboxyl groups on TOCNFs. The NCAs reveal distinct anisotropy, excellent mechanical compressibility in the radial direction, and high water-stability. To demonstrate their promising potentials for application in various advanced fields such as solar steam generation, the NCA is coated with polypyrrole (PPy) by in-situ polymerization to achieve excellent photothermal property but well maintain the original aligned channels of NCA, which endow the NCA@PPy with an efficient solar evaporation performance.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Bioprinting is an emerging technology for manufacturing cell-laden three-dimensional (3D) scaffolds, which are used to fabricate complex 3D constructs and provide specific microenvironments for ...supporting cell growth and differentiation. The development of bioinks with appropriate printability and specific bioactivities is crucial for bioprinting and tissue engineering applications, including bone tissue regeneration. Therefore, to produce functional bioinks for osteoblast printing and bone tissue formation, we formulated various nanocomposite hydrogel-based bioinks using natural and biocompatible biomaterials (i.e., alginate, tempo-oxidized cellulose nanofibrils (TOCNF), and polydopamine nanoparticles (PDANPs)). Rheological studies and printability tests revealed that bioinks containing 1.5% alginate and 1.5% TOCNF in the presence or absence of PDANP (0.5%) are suitable for 3D printing. Furthermore, in vitro studies of 3D-printed osteoblast-laden scaffolds indicated that the 0.5% PDANP-incorporated bioink induced significant osteogenesis. Overall, the bioink consisting of alginate, TOCNF, and PDANPs exhibited excellent printability and bioactivity (i.e., osteogenesis).
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP