Prognosis research should be a basic science in translational medicine, but methodological problems mean systematic reviews are unable to reach firm conclusions. Harry Hemingway and colleagues ...recommend action to improve the quality
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Parts of Africa experience persistent violence and seemingly intractable conflicts. These generally have deep historical roots dating to colonial periods and before, and many of them have become more ...destructive in the post-Cold war period. These violent conflicts have drawn researchers seeking to determine and explain why conflicts are prevalent, what makes them intensify, and how conflicts can be resolved. However much of the literature on research methodology does not address the complexities of conducting research in the midst of violent conflict and massive ethno-political disputes. This publication examines the ethical and practical issues of researching within violent and divided societies, drawing on case studies from Angola, the Democratic Republic of Congo, Ghana, Nigeria, Rwanda and South Africa.
Igniting Innovation Itzhak Goldberg, John Gabriel Goddard, Smita Kuriakose, Jean-Louis Racine
2011, 09-22-2011, 2011-09-22, 20110101
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This book builds on the lessons from public institutions and programs to support innovation, both successful and failed, from Europe and Central Asia (ECA) as well as China, Finland, Israel, and the ...United States. Field visits to these countries were hosted by the innovation and scientific agencies of the respective governments, strengthening the international experiences presented here. This book is a culmination of ten years of analytic and operational work led by the private and financial sector development department and the chief economist's office of the ECA region of the World Bank. Several regional reports and country policy notes exploring these issues have been published over the years. The book also reflects the lively discussion in the ongoing series of flagship events to promote knowledge based economies in the region. The most recent knowledge economy forum was held in Berlin in 2010, hosted by the fraunhofer center for Central and Eastern Europe. The book identifies policies that have an adverse affect on innovation. It also identifies policy gaps that, if filled, could have a catalytic effect on private sector innovation.
Discipline‐based education research (DBER) conducted by faculty within geoscience departments can address identified needs in undergraduate geoscience education. This study explores the evolution of ...undergraduate geoscience education research (GER) from 1985 to 2016, primarily in terms of the types of published research and secondarily in terms of the insights this literature offers on the evolution of GER as a scholarly discipline. Stokes’ (1997) quadrant model of research types is used as a theoretical framework for the former and Kuhn's (1970) model of disciplinary paradigm for the latter. An exploratory sequential mixed‐methods approach to a systematic literature review of 1,760 articles is utilized. The period 1985–2000 is characterized by proto‐research as evidenced by the abundance of instructive and informational education articles rather than research articles. From 2000 to 2011, GER underwent a growth period characterized by the presence of applied, use‐inspired, and pure basic research. The period 2011–2016 appears to be a period of relative steady‐state conditions in the normalized number of GER publications per year. Existing gaps in knowledge about geoscience education, the evident unfamiliarity with education and social science research methodologies among authors of GER articles, and efforts to build consensus about what GER is and how to conduct it suggest that GER is preparadigmatic or at a low paradigm state. That is, GER is an immature discipline as far as the evolution of a discipline goes. A path forward is proposed for the continued evolutionary growth of GER. This study provides new perspectives on the emergence of GER as a discipline that can be used as a basis for studies on cross‐disciplinary DBER comparisons.
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Characterization of the tissue light penetration in prostate photodynamic therapy (PDT) is important to plan the arrangement and weighting of light sources so that sufficient light fluence is ...delivered to the treatment volume. The optical properties (absorption μa, transport scattering μs′ and effective attenuation μeff coefficients) of 13 patients with locally recurrent prostate cancer were measured in situ using interstitial isotropic detectors. Measurements were made at 732 nm before and after motexafin lutetium (MLu)–mediated PDT in four quadrants. Optical properties were derived by applying the diffusion theory to the fluence rates measured at several distances (0.5–5 cm) from a point source. μa and μs′ varied between 0.07 and 1.62 cm−1 (mean 0.37 ± 0.24 cm−1) and 1.1 and 44 cm−1 (mean 14 ± 11 cm−1), respectively. μa was proportional to the concentration of MLu measured by an ex vivo fluorescence assay. We have observed, on average, a reduction of the MLu concentration after PDT, presumably due to the PDT consumption of MLu. μeff varied between 0.91 and 6.7 cm−1 (mean 2.9 ± 0.7 cm−1), corresponding to an optical penetration depth (δ = 1/μeff) of 0.1–1.1 cm (mean 0.4 ± 0.1 cm). The mean penetration depth at 732 nm in human prostate is at least two times smaller than that found in normal canine prostates, which can be explained by a four times increase of the mean value of μs′ in human prostates. The mean light fluence rate per unit source strength at 0.5 cm from a point source was 1.5 ± 1.1 cm−2, excluding situations when bleeding occurs. The total number of measurements was N = 121 for all mean quantities listed above. This study showed significant inter- and intraprostatic differences in the optical properties, suggesting that a real-time dosimetry measurement and feedback system for monitoring light fluences during treatment should be considered for future PDT studies.
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Missing data are a common occurrence in survey-based research studies in education, and the way missing values are handled can significantly affect the results of analyses based on such data. Despite ...known problems with performance of some missing data handling methods, such as mean imputation, many researchers in education continue to use those methods as a quick fix. This study reviews the current literature on missing data handling methods within the special context of education research to summarize the pros and cons of various methods and provides guidelines for future research in this area.
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First calls for mission proposals are expected by the end of this year. ...after market launch, entrepreneurs will be able to request EIC 'accelerator' support - including grants, loans and coaching ...services - to expand their businesses. The scheme will continue to use tried-and-tested tactics, such as teaming leading research institutions with ones that are less well-established, providing special grants for top researchers in countries that joined the EU only recently, and training researchers to improve their grant-writing and project-management skills.
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Choosing a suitable sample size in qualitative research is an area of conceptual debate and practical uncertainty. That sample size principles, guidelines and tools have been developed to enable ...researchers to set, and justify the acceptability of, their sample size is an indication that the issue constitutes an important marker of the quality of qualitative research. Nevertheless, research shows that sample size sufficiency reporting is often poor, if not absent, across a range of disciplinary fields.
A systematic analysis of single-interview-per-participant designs within three health-related journals from the disciplines of psychology, sociology and medicine, over a 15-year period, was conducted to examine whether and how sample sizes were justified and how sample size was characterised and discussed by authors. Data pertinent to sample size were extracted and analysed using qualitative and quantitative analytic techniques.
Our findings demonstrate that provision of sample size justifications in qualitative health research is limited; is not contingent on the number of interviews; and relates to the journal of publication. Defence of sample size was most frequently supported across all three journals with reference to the principle of saturation and to pragmatic considerations. Qualitative sample sizes were predominantly - and often without justification - characterised as insufficient (i.e., 'small') and discussed in the context of study limitations. Sample size insufficiency was seen to threaten the validity and generalizability of studies' results, with the latter being frequently conceived in nomothetic terms.
We recommend, firstly, that qualitative health researchers be more transparent about evaluations of their sample size sufficiency, situating these within broader and more encompassing assessments of data adequacy. Secondly, we invite researchers critically to consider how saturation parameters found in prior methodological studies and sample size community norms might best inform, and apply to, their own project and encourage that data adequacy is best appraised with reference to features that are intrinsic to the study at hand. Finally, those reviewing papers have a vital role in supporting and encouraging transparent study-specific reporting.
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