Influenza Uyeki, Timothy M; Hui, David S; Zambon, Maria ...
The Lancet (British edition),
01/2022, Volume:
400, Issue:
10353
Journal Article
Peer reviewed
Open access
Annual seasonal influenza epidemics of variable severity caused by influenza A and B virus infections result in substantial disease burden worldwide. Seasonal influenza virus circulation declined ...markedly in 2020–21 after SARS-CoV-2 emerged but increased in 2021–22. Most people with influenza have abrupt onset of respiratory symptoms and myalgia with or without fever and recover within 1 week, but some can experience severe or fatal complications. Prevention is primarily by annual influenza vaccination, with efforts underway to develop new vaccines with improved effectiveness. Sporadic zoonotic infections with novel influenza A viruses of avian or swine origin continue to pose pandemic threats. In this Seminar, we discuss updates of key influenza issues for clinicians, in particular epidemiology, virology, and pathogenesis, diagnostic testing including multiplex assays that detect influenza viruses and SARS-CoV-2, complications, antiviral treatment, influenza vaccines, infection prevention, and non-pharmaceutical interventions, and highlight gaps in clinical management and priorities for clinical research.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Cet ouvrage s’intéresse au risque et à la vigilance face à la peste sur la côte méditerranéenne française dans la première moitié du 18e siècle. Entre 1720 et 1722, une terrible épidémie de peste ...frappe Marseille, la Provence, le Comtat-Venaissin et une partie du Languedoc, causant environ 100'000 décès. Aussi dramatique soit-elle, cette épidémie constitue une exception durant la première moitié du 18e siècle. La première partie de ce travail analyse les rapports entre vigilance, espace et communication et met en évidence une prévention qui s’exerce tant de manière transméditerranéenne que de manière interne au royaume de France. Une véritable «bureaucratie sanitaire» se met en place. La deuxième partie étudie les normes et les pratiques de la vigilance sanitaire, tant sur un plan politico-sanitaire (quarantaines des navires, des passagers et des marchandises) que sur un plan religieux (processions et prières pour endiguer la maladie). Enfin, la dernière partie se limite à la peste de 1720-1722 et illustre le passage d’une vigilance préventive à une vigilance réactive en s’intéressant aux «acteurs de la peste» et aux attitudes et tactiques développées face au fléau épidémique.
Akkadian Royal Letters in Later Mespotamian Tradition reconsiders the question of the authenticity of the letters attributed to earlier royal correspondents that were studied in Assyrian and ...Babylonian scribal centres ca. 700–100 BCE. By scrutinizing the letters’ contents, language, possible transmission histories ca. 1400–100 BCE and the epistemic limitations of authenticity criticism, the book grounds scepticism about the letters’ authenticity in previously undiscussed features of the texts. It also provides a new foundation for research into the related questions of when and why these beguiling texts were composed in the first place.
Die COVID-19 Task Force der European Society of Hypertension (ESH) hat sich in einem Review erneut zur Bedeutung von Bluthochdruck und therapeutischer RAS-Blockade bei COVID-19-Patienten geäußert. ...Dargestellt und kritisch diskutiert werden v. a. die molekularen Mechanismen der Infektion und der RAS-Hemmung sowie die potenziellen klinischen Implikationen.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Seminar Inovasi Pembelajaran Berbasis Tematik Baidowi, Ach; Abdussalam, Abdussalam
Jurnal Pengabdian Masyarakat dan Penelitian Thawalib,
02/2023, Volume:
2, Issue:
1
Journal Article
Peer reviewed
Open access
Thematic learning becomes very important in the era of the 2013 curriculum and also the current independent learning curriculum, the output of the two curricula is strengthening the processes and ...learning outcomes for students. The seminar was conducted with the aim of strengthening and increasing the teacher's pegagogical competence, especially in terms of learning innovation. The seminar was conducted offline with a duration of 200 minutes on August 29 2022 at UPTD SDN Pangilen 3 Sampang which was attended by 8 teachers. The speaker uses the help of a laptop as a medium for delivering material. The results of the seminar implementation: 1) The first speaker gave material about holistic and meaningful learning, the second speaker gave authentic and active learning material. 2) The seminar runs actively as evidenced by lively discussions. 3) The results of the teacher's seminar increasingly understand and can practice holistic, meaningful, authentic and active learning in front of the presenters. The impact of this seminar is as a reference material and study for other schools, especially rural schools that have not implemented thematic learning as a whole.
Coronavirus and Cardiometabolic Syndrome Mechanick, Jeffrey I.; Rosenson, Robert S.; Pinney, Sean P. ...
Journal of the American College of Cardiology,
10/2020, Volume:
76, Issue:
17
Journal Article
Peer reviewed
Open access
The coronavirus disease 2019 (COVID-19) pandemic exposes unexpected cardiovascular vulnerabilities and the need to improve cardiometabolic health. Four cardiometabolic drivers—abnormal adiposity, ...dysglycemia, dyslipidemia, and hypertension—are examined in the context of COVID-19. Specific recommendations are provided for lifestyle change, despite social distancing restrictions, and pharmacotherapy, particularly for those with diabetes. Inpatient recommendations emphasize diligent and exclusive use of insulin to avert hyperglycemia in the face of hypercytokinemia and potential islet cell injury. Continuation of statins is advised, but initiating statin therapy to treat COVID-19 is as yet unsubstantiated by the evidence. The central role of the renin-angiotensin system is discussed. Research, knowledge, and practice gaps are analyzed with the intent to motivate prompt action. An emerging model of COVID-related cardiometabolic syndrome encompassing events before, during the acute phase, and subsequently in the chronic phase is presented to guide preventive measures and improve overall cardiometabolic health so future viral pandemics confer less threat.
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COVID-19 exposes epidemiological and mechanistic relationships with cardiometabolic links (abnormal adiposity, dysglycemia, dyslipidemia, and hypertension).
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Lifestyle, glycemic control, and regulation of the RAS have important implications for management of patients with COVID-19.
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CIRCS applies to all stages of COVID-19 illness, including prevention, acute management, and long-term outcomes.
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Further research should address gaps in current knowledge and clinical implementation of available strategies to mitigate the adverse consequences of CIRCS.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The emergence of a new coronavirus disease (coronavirus disease 2019 COVID-19) has raised global concerns regarding the health and safety of a vulnerable population. Infection with severe acute ...respiratory syndrome coronavirus 2 (SARS-CoV-2) incites a profound inflammatory response leading to tissue injury and organ failure. COVID-19 is characterized by the bidirectional relationship between inflammation and thrombosis. The clinical syndrome is propelled by inflammation producing acute lung injury, large-vessel thrombosis, and in situ microthrombi that may contribute to organ failure. Myocardial injury is common, but true myocarditis is rare. Elderly patients, those with established cardiovascular disease, and mechanically ventilated patients face the highest mortality risk. Therapies for COVID-19 are evolving. The antiviral drug remdesivir, dexamethasone, transfusion of convalescent plasma, and use of antithrombotic therapy are promising. Most require additional prospective studies. Although most patients recover, those who survive severe illness may experience persistent physical and psychological disabilities.
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Severe acute respiratory syndrome coronavirus 2 infection (COVID-19) is a global pandemic affecting millions of people worldwide.
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Clinical sequelae result largely from an intense inflammatory response triggering large-vessel and microvascular thrombosis.
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No therapy has been universally effective for COVID-19, but systemic anticoagulation, remdesivir, and corticosteroids hold promise.
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Long-term sequelae of COVID-19 are variable and incompletely defined, but physical and psychological disabilities can persist.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The cardiovascular system is affected broadly by severe acute respiratory syndrome coronavirus 2 infection. Both direct viral infection and indirect injury resulting from inflammation, endothelial ...activation, and microvascular thrombosis occur in the context of coronavirus disease 2019. What determines the extent of cardiovascular injury is the amount of viral inoculum, the magnitude of the host immune response, and the presence of co-morbidities. Myocardial injury occurs in approximately one-quarter of hospitalized patients and is associated with a greater need for mechanical ventilator support and higher hospital mortality. The central pathophysiology underlying cardiovascular injury is the interplay between virus binding to the angiotensin-converting enzyme 2 receptor and the impact this action has on the renin-angiotensin system, the body’s innate immune response, and the vascular response to cytokine production. The purpose of this review was to describe the mechanisms underlying cardiovascular injury, including that of thromboembolic disease and arrhythmia, and to discuss their clinical sequelae.
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The cardiovascular system is affected in diverse ways by severe acute respiratory syndrome coronavirus 2 infection (COVID-19).
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Myocardial injury can be detected in ∼25% of hospitalized patients with COVID-19 and is associated with an increased risk of mortality.
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Described mechanisms of myocardial injury in patients with COVID-19 include oxygen supply–demand imbalance, direct viral myocardial invasion, inflammation, coronary plaque rupture with acute myocardial infarction, microvascular thrombosis, and adrenergic stress.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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