Da un’analisi approfondita dei testi epigrafici di Roma relativi ai restauri di terme o di altre strutture idriche ad esse correlate, sembrano emergere, dalla fine del III sec. d.C., due aspetti fino ...ad ora poco approfonditi: in primo luogo, un’attenzione per l’uso di termini tecnici dettagliati per descrivere le parti degli edifici coinvolte nei lavori, senza a volte trascurare di menzionare l’ornato e i materiali utilizzati; in seconda istanza, compare un riferimento, spesso esplicito, ai bisogni e al desiderio dei cittadini, destinatari sociali dell’intervento. Sulla base di queste premesse, si è voluto estendere l’indagine all’Africa romana per comprendere se quanto emerso per Roma e altre realtà geografiche, nel medesimo ambito cronologico, sia valido anche per le province nordafricane, che si distinguono per il ricco patrimonio epigrafico, e per l’elevata percentuale di esso riguardante opere pubbliche e edifici termali in particolare.
Heritage, protection, and responsibility are prerequisites and cornerstones for a research project conducted in the Berzantina primary school, part of the Comprehensive Institute of Porretta Terme, ...in the province of Bologna. It is a project to discover the local heritage, its care and protection to achieve awareness of the importance of taking responsibility as inhabitants and active citizens of a town. The project is based on the ancient establishments of the Terme Alte of Porretta, which, for years now, have been in a state of decline and abandonment. This project aims to introduce students to local history through direct, photographic, artistic, and filmographic testimonies. The idea is to combine the teaching of local history with the protection of the historical- artistic heritage, actively involving children as inhabitants of the area and above all as future citizens.
•Terme di Baia is one of the most important archaeological sites in Southern Italy.•Microstructural and compositional examination of coating mortars.•Long-lasting use of a valuable mix design created ...with local raw materials.•Secondary phases improved the technological properties of mortars.
Ancient pozzolanic mortars show the high technological quality achieved by Roman construction workers, due to their ‘excellent state’ of preservation in every environment. These workers well knew that thanks to the combination of lime with specific volcanic products (pozzolana), mortar and concrete become hydraulic, allowing underwater hardening and increasing mechanical strength. The use of pozzolana in a mortar provides the underwater curing (hydraulic limes) of whatever construction with higher speed compared to carbonation processes of slaked lime. Whenever pozzolana is not available, it is substituted by ceramic fragments, which possess similar hydraulic properties. This research focuses, for the first time, on the detailed characterization of mortars coming from the Thermal Complex of Baia, which represents one of the most important archaeological sites in the Campania region. Thanks to several thermal springs, the ancient city of Baiae (Campi Flegrei) was the holiday resort of the Roman aristocracy. The former Soprintendenza Archeologia della Campania, allowed us to perform non-invasive, but representative, sampling of mortars that were characterised by multianalytical methodologies (POM, XRPD, SEM-EDS, TGA, and MIP) providing useful information on possible future activities of restoration. Results confirmed the expertise of Roman workers, who skilfully combined volcanic tuff aggregate, hydrated lime, and ceramic fragments. In particular, the typical zeolitic mineral association of phillipsite>chabazite>analcime found in the tuff aggregate pointed out their provenance from the Neapolitan Yellow Tuff related to the volcanic activity of Campi Flegrei of ca. 15ka BP. The most relevant characteristic detected in all studied samples is the mortar hydraulicity testified by evidences such as reaction rims between pozzolana and binder, Hydraulicity Index (HI), and thermal analyses investigation. Also, composition of secondary mineralogical phases in the cementiceous matrix is particularly relevant. Distinctive is the contemporary presence of C-A-S-H gel, calcite and gypsum. C-A-S-H gel is derived from lime/ceramic fragments reaction; calcite is likely related to the partial reaction of underburned lime; and gypsum could be ascribable to the sulphation process of calcite. These secondary minerogenetic products fill pore space and enhance bonding in pumice fragments, thus contributing to long-term durability of mortars.
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In recent years, interest-rate modeling has developed rapidly in terms of both practice and theory. The academic and practitioners' communities, however, have not always communicated as productively ...as would have been desirable. As a result, their research programs have often developed with little constructive interference. In this book, Riccardo Rebonato draws on his academic and professional experience, straddling both sides of the divide to bring together and build on what theory and trading have to offer.
Rebonato begins by presenting the conceptual foundations for the application of the LIBOR market model to the pricing of interest-rate derivatives. Next he treats in great detail the calibration of this model to market prices, asking how possible and advisable it is to enforce a simultaneous fitting to several market observables. He does so with an eye not only to mathematical feasibility but also to financial justification, while devoting special scrutiny to the implications of market incompleteness.
Much of the book concerns an original extension of the LIBOR market model, devised to account for implied volatility smiles. This is done by introducing a stochastic-volatility, displaced-diffusion version of the model. The emphasis again is on the financial justification and on the computational feasibility of the proposed solution to the smile problem. This book is must reading for quantitative researchers in financial houses, sophisticated practitioners in the derivatives area, and students of finance.
DMF demonstrated strong efficacy and a favourable benefit-risk profile in RRMS patients in Phase 3 studies (DEFINE/CONFIRM), which is sustained in the extension study, ENDORSE.
To evaluate efficacy ...in newly diagnosed patients with RRMS treated with DMF for ∼9 years.
An integrated analysis of newly diagnosed patients who continued after 2 years onto the ENDORSE study assessed annualised relapse rate (ARR) and EDSS score. Results are reported for patients treated with DMF 240mg BID: placebo (PBO)/DMF (PBO for Years 0–2/DMF for Years 3–9) or continuous (DMF/DMF) treatment.
The observed proportion of patients with EDSS≤3.5 was 129/139 (93%) and 65/72 (90%) at Year 2, and 50/54 (93%) and 26/28 (93%) at Year 9 for DMF/DMF and PBO/DMF, respectively. For PBO/DMF, adjusted ARR (95% CI) was 0.25 (0.18–0.37) for Years 0–2 (PBO) and 0,09 (0,06–0.14) for Years 3–9 (DMF).
NA.
The majority of patients remaining on study maintained walking abilities (EDSS≤3.5) over 9 years and ARR remained low.
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Rad ukazuje na pronađene fragmente iz samostana benediktinki Sv. Roka u Rijeci čije se arhivsko gradivo danas nalazi u samostanu Sv. Danijela u Abano Terme u Italiji, gdje su riječke redovnice ...izbjegle nakon Drugog svjetskog rata. Od tri pronađena, članak opisuje jedan glagoljski fragment na uglatoj glagoljici kojemu pristupa kroz paleografsku, kodikološku, teološko i liturgijsko-povijesnu analizu. Donosi se transliteracija teksta i zaključuje se da je fragment pripadao brevijaru iz razdoblja kraja 14. ili 15. stoljeća te da je vezan uz liturgijsko svetkovanje sv. Martina biskupa i ispovjednika. Pronalazak fragmenta smješta se u dosadašnje spoznaje o liturgijsko-jezičnoj povijesti Rijeke i iznose se hipoteze o načinu na koji je dospio u samostan riječkih benediktinki, zajednicu koju se smatra latinaškom.
In the thus far unexplored archives of the monastery of the Benedictine nuns of St. Rochus in Rijeka, which have been located at the Monastery of St. Daniel in Abano Terme, Italy, since the exodus of Italians from lands annexed by Croatia in the aftermath of World War II, a corpus of three previously unknown fragments consisting of two fragments written in the Glagolitic script in Old Church Slavonic and one in the Latin script in Latin was discovered. These fragments were found in a book related to the management of Franjo Knežić’s endowment for the construction of the monastery. This paper analyses one of the Glagolitic fragments. The fragment, which is written in angular Glagolitic script, is
analysed from the palaeographic, codicological, theological, and liturgical-historical perspective. The transliteration of the text is provided, and it is concluded that the fragment came from a breviary from the end of the 14th or from the 15th century, and that it was related to the liturgical celebration of St. Martin, Bishop and Confessor. The discovery of the fragment is placed within the context of the liturgical-linguistic history of Rijeka, and hypotheses on the way in which it came to be in the possession of the Benedictine nuns from Rijeka, who were considered a Latin monastic community, are formed.
La rupture prématurée des membranes (RPM) à terme survient dans 5 à 10% des grossesses. Elle rend compte d'une part importante de morbidité et de mortalité néonatales. Le but de cette étude est de ...déterminer les facteurs pronostiques maternels et obstétricaux ainsi que le devenir des nouveau-nés à terme issus d'une grossesse compliquée de rupture prématurée des membranes ayant été hospitalisés au service ou gérés à la consultation externe. Etude rétrospective, analysant toutes les observations de nouveau-nés à terme issus de grossesses compliquées de RPM, enregistrées au service de néonatologie de l'hôpital d'enfants de Rabat entre le 1er janvier et le 31 juillet 2014. Au cours de la période d'étude nous avons colligé 144 cas de RPM isolée sur un total de 2400 naissances vivantes (NV) soit une prévalence de 6% NV, répartis comme suit : 06 cas de RPM (4%) entre 6 et 12 heures, 14 cas (9,7%) entre 12 et 18 heures, 28 cas (19,4%) entre 18 et 24 heures et 96 cas (66,6%) supérieure à 24 heures. La majorité de nos parturientes étaient dans la tranche d'âge de 25 à 35ans avec un taux de 52%. Une chorioamniotite associée a été retenue dans 8,3% des cas. Les parturientes ont été mises sous antibiothérapie prophylactique par voie orale ou parentérale dans 28% des cas, avec un liquide amniotique clair dans 81% des cas. Le diagnostic d'IMF probable a été retenu dans 46 cas dont 65.2 % dans le sous groupesupérieur à 18 h versus respectivement 26% et 8,7% dans les sous groupe 12 à 18 h et inférieur à 12 h. A l'admission, on a noté une prédominance masculine avec 58,3%, les nouveau-nés étaient asymptomatiques dans 76% des cas et ils présentaient une détresse respiratoire dans 42,8% des cas, un ictère dans 31,45% des cas, une fièvre dans 14,2% des cas et des signes de souffrance neurologique dans 11,5% des cas. Tous les nouveau-nés hospitalisés, soit dans 72% des cas, ont été mis sous antibiothérapie pendant une durée allant de 5 à 10 jours avec une durée d'hospitalisation moyenne de 2,44jours. Ce travail souligne le risque important d'IMF associé à une RPM même à terme. Ce risque est d'autant plus important que la rupture est supérieure à 24 heures de temps. Dans la majorité des cas le liquide amniotique est clair et les nouveau-nés sont asymptomatiques à l'admission, ce qui laisse la mise sous antibiothérapie automatiquement de ces nouveau-nés un sujet encore très discutable.
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•Cold load prediction of shopping malls considering functional zones.•Selection of factors impacting cooling load in shopping mall functional zones.•Applies LSTM network with dual attention mechanism ...to optimize the output of the prediction model.
Prediction of cooling load for each functional zone is essential for implementing an efficient and economic energy management plan in shopping mall. While previous research has been concerned with the overall cooling load prediction of the shopping mall, which could not provide a reasonable control strategy for the on-demand cooling of functional zone in shopping malls. To address this, we present a novel approach to predict cooling load of functional zones in shopping mall which first uses gray relational analysis methods to screen the key influencing factors of cooling load considering the characteristics of cooling load for different functional zones in shopping mall. It then applies LSTM with dual attention mechanism to optimize the output of the prediction model. Feature attention extracts important features through the analysis of the relationship between historical information and input variables autonomously, while temporal attention improves the prediction accuracy by analyzing the importance of load of each historical moment to the prediction of time load. We evaluate the performance of the proposed approach using real data sets from a shopping mall, which locates at Xi 'an, in the north of China. Experimental results show that cooling load prediction based on function zones may not only better satisfy the cooling load demand of diverse zones, but also ensure that chilled water is available on demand for air conditioning systems. Meanwhile, the short-time zonal cooling load prediction model based on dual-attention-LSTM has increased prediction accuracy, generalization ability, and stability when compared to previous prediction models.
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Evobrutinib (EVO), inhibiteur très sélectif de la tyrosine kinase de Bruton (BTKi), réduit l’activation des lymphocytes B et cellules myéloïdes impliqués dans la pathogénie de la sclérose en plaques ...(SEP).
Après démonstration de l’efficacité d’EVO dans le traitement de la SEP rémittente en semaine 24 puis 48 lors d’une étude de phase II, l’objectif est d’évaluer l’efficacité à long terme.
Durant l’essai initial en double aveugle, les patients ont reçu EVO 25mg 1×/jour (QD), 75mg QD, 75mg 2×/jour (BID) ou placebo (PBO) pendant 24 semaines, puis chaque bras a poursuivi le même traitement jusqu’à la semaine 48 sauf le groupe PBO qui a reçu EVO 25mg QD. Après la semaine 48, les patients entrant dans la phase d’extension (OLE) ont d’abord été traités avec EVO 75mg QD avant de switcher à 75mg BID.
Pour les patients ayant reçu initialement PBO ou EVO 25mg QD, 75mg QD ou 75mg BID, le taux annualisé de poussées (TAP) était de 0,31, 0,37, 0,18 et 0,12 respectivement en semaine 108. Le temps estimé pour que 20 % de patients présentent une poussée était 3 fois plus long chez les patients initialement traité par EVO 75mg BID versus PBO et également plus long par rapport aux patients traités par EVO 25mg QD, 75mg QD.
Avec EVO 75mg BID, l’efficacité (TAP, 0,11) en semaine 48 était maintenue en semaine 108. Les résultats concernant la probabilité de survenue et durée avant poussée mettent en évidence que les patients traités par EVO 25mg QD, 75mg QD ou PBO n’ont pas atteint le même niveau d’efficacité que ceux traités par EVO 75mg BID.
L’efficacité maximum observée avec EVO 75mg BID est en corrélation avec l’occupation optimale de la BTK atteinte grâce à la double prise journalière d’evobrutinib.
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