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Uporaba infrardeče spektroskopske semi-kvantitativne metode za določitev ocene topnosti luteolina v vodi, nepolarnih in polarnih topilih = Estimated solubility determination of luteolin in water, nonpolar and polar solvents by applying infrared spectroscopic semi-quantitative method : magistrska naloga : enoviti magistrski študij farmacijeRajhard, SašaV zadnjih letih so flavonoidi zaradi svojih številnih učinkov na zdravje človeka postali pogosto raziskovana tema v znanosti. Topnost flavonoidov ima velik pomen v farmacevtski, prehranski in ... kemijski industriji, zato je določitev ustreznih topil zelo pomembna. Spektrometrično analizo FTIR-ATR (angl. Fourier Transform Infrared – Attenuated Total Reflection) smo izvedli na nekaterih flavonoidih in fenolnih spojinah: luteolinu, hesperidinu, kvercetinu, naringeninu ter galni in taninski kislini. Kot modelno snov za podrobnejše raziskave smo izbrali luteolin ter določili korelacije med njegovo vsebnostjo in transmitanco v 12 topilih različne polarnosti. Na osnovi kalibracijskih krivulj smo določili ocene topnosti in jih primerjali z vrednostmi, določenimi s tekočinsko kromatografijo visoke ločljivosti (angl. High-Performance Liquid Chromatography – HPLC). Z obema uporabljenima metodama smo pridobili enak vrstni red topnosti luteolina. Kot najboljši topili sta se v obeh primerih izkazali dimetilsulfoksid (DMSO) in tetrahidrofuran (THF), nato pa je topnost luteolina v topilih upadala po naslednjem vrstnem redu: propanol > etanol > aceton > butanol > metanol > etil acetat > dietil eter > acetonitril > diklorometan > voda. Analiza s HPLC je pri vsebnosti luteolina 20 mg/mL pokazala, da se je celotna količina luteolina raztopila v topilih DMSO in THF, v propanolu je bila topnost 18,1 ± 0,001 mg/mL, v etanolu 18,0 ± 1,4 mg/mL, v acetonu 16,7 ± 2,3 mg/mL, v butanolu 15,9 ± 0,4 mg/mL, v metanolu 6,1 ± 1,0 mg/mL, v etil acetatu 2,9 ± 0,3 mg/mL, v dietil etru 0,7 ± 0,2 mg/mL, v acetonitrilu 0,6 ± 0,1 mg/mL, v diklorometanu 0,002 ± 0,0002 mg/mL in v vodi 0,004 ± 0,0002 mg/mL. Rezultati predstavljajo prikaz uporabe metode FTIR-ATR kot semikvantitativnega orodja za določitev ocene topnosti različnih spojin, ki omogoča prihranek velike količine topil in časa.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [S. Rajhard], 2022Language - slovenianCOBISS.SI-ID - 121426691
Author
Rajhard, Saša
Other authors
Srčič, Stanko |
Likozar, Blaž
Topics
Flavonoidi |
Topnost |
luteolin |
FTIR-ATR |
HPLC |
tekočinska kromatografija visoke ločljivosti
Library | Call number – location, accession no. ... | Copy status |
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Faculty of Pharmacy, Lj. | Knjižnica emšf 544 RAJHARD SAŠA Uporaba 1119 IN: 0017384 |
available - reading room |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Rajhard, Saša | |
Srčič, Stanko | 09031 |
Likozar, Blaž | 25446 |
Source: Personal bibliographies
and: SICRIS
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