Pharmacokinetic study of famotidine was performed in the dog, in order to compare the parameters obtained from plasma and urine data. Calculation of pharmacokinetic parameters of famotidine from ...urine data is feasible; however to obtain good estimates, the cumulative amounts excreted in urine should be determined in short time intervals, namely less than 20 minutes. Elimination constants thus obtained belong to the terminal (beta) phase only.
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