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Real-world outcomes of immunotherapy with or without chemotherapy in first-line treatment of advanced non-small cell lung cancer [Elektronski vir]Pelicon, Veronika ; Čufer, Tanja, 1955- ; Knez, Lea, 1981-Background: Immunotherapy alone (mono-IT) or combined with chemotherapy (chemo-IT) has recently become the cornerstone of first-line treatment for advanced non-small cell lung cancer (NSCLC) ... patients. Here, real-world outcomes of first-line mono-IT and chemo-IT of advanced NSCLC treated within routine clinical practice at a single academic center in the Central Eastern European (CEE) region are presented. Materials and methods: A total of 176 consecutive patients with advanced NSCLC treated with mono-IT (118 patients) or chemo-IT (58 patients) were included. At the participating institution, all medical data relevant for providing oncology care are collected prospectively and in a standardized manner using purposely created pro-forms. Adverse events (AEs) were recorded and graded according to Common Terminology Criteria for Adverse Events (CTCAE). The Kaplan−Meier method was used to estimate median overall survival (mOS) and median duration of treatment (mDOT). Results: The 118 patients in the mono-IT cohort had a median age of 64 years, most were male (59%), 20% had ECOG PS ≥2, and 14% had controlled CNS metastases at baseline. With a median follow-up time (mFU) of 24.1 months, the mOS was 19.4 months (95% CI, 11.1-27.6), and the mDOT was 5.0 months (95% CI, 3.5-6.5). The 1-year OS was 62%. The 58 patients in the chemo-IT cohort had a median age of 64 years, most were male (64%), 9% had ECOG PS ≥2, and 7% had controlled CNS metastases at baseline. With a mFU of 15.5 months, the mOS was 21.3 months (95% CI, 15.9-26.7), and the mDOT was 12.0 months (95% CI, 8.3-15.6). The 1-year OS was 75%. Adverse events of severe grade were recorded in 18% and 26% of patients, and immunotherapy discontinuation due to AEs occurred in 19% and 9% in the mono-IT and chemo-IT groups, respectively. No treatment-related deaths were recorded. Conclusion: The results from the present real-world observational study from a CEE country suggest similar effectiveness and safety of first-line mono-IT and chemo-IT in patients with advanced NSCLC to those observed in randomized clinical trials. However, continuous follow-up will offer better insight into the magnitude of long-term benefits in routine clinical practice.Source: Frontiers in oncology [Elektronski vir]. - ISSN 2234-943X (Vol. 13, art. 1182748, 2023, 11 str.)Type of material - e-article ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 157113347
Author
Pelicon, Veronika |
Čufer, Tanja, 1955- |
Knez, Lea, 1981-
Topics
Imunoterapija |
Kemoterapija |
Rak (medicina) |
non-small cell lung cancer |
immunotherapy |
chemo-immunotherapy |
realworld outcomes |
first line |
nedrobnocelični pljučni rak |
kemo-imunoterapija |
realni rezultati |
prva linija
Author | Pelicon, Veronika ; Čufer, Tanja, 1955- ; Knez, Lea, 1981- |
Title | Real-world outcomes of immunotherapy with or without chemotherapy in first-line treatment of advanced non-small cell lung cancer [Elektronski vir] |
Publication date | 2023-06-19 |
COBISS.SI-ID | 157113347 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih | P1-0189-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Celostna obravnava alergijskih bolezni in astme v Sloveniji: od epidemiologije do genetike | P3-0360-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Files that belong to the publication
Link |
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https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1182748/full |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=147298 |
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Database name | Field | Year |
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Pelicon, Veronika | |
Čufer, Tanja, 1955- | 12179 |
Knez, Lea, 1981- | 29281 |
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