A model of CHO-215 semi-intact cells was used for the study of the regulatory mechanisms of HMGCoA reductase at the postranslational level. In such a systemby removing a portion of the plasma ...membrane large perforations are created that allow the release of soluble cytoplasmic components but leave theintracellular organelles intact. The short term effect of cholesterol and non-sterol intermediates of the isoprenoid pathway on HMGCoA reductase activity was stidied by monitoring enzyme activities of solubilized enzyme andintact enzyme in situ. Elevated levels of cholesterol always resulted in a decrease of enzyme activity in semi-intact CHO-215 independendt of the way that enzyme activity, was measured. Among non-sterol intermediates of the isoprenoid pathway, famesol was found to increase the HMGCoA reductase activity.
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