-
Halogenation of common phenolic household and personal care product ingredients enhances their AhR-modulating capacityWeiss, Veronika, farmacevtka ; Gobec, Martina, 1983- ; Jakopin, ŽigaThe Aryl Hydrocarbon Receptor (AhR), a ligand-activated transcription factor, orchestrates responses to numerous structurally diverse endogenous and exogenous ligands. In addition to binding various ... xenobiotics, AhR also recognizes endocrine disruptors, particularly those featuring chlorinated or brominated aromatic structures. There is limited data available on the impact of common household and personal care product ingredients let alone their halogenated transformation products. Herein we bridge this knowledge gap by preparing a library of chlorinated and brominated parabens, bisphenols, UV filters, and nonylphenols. An evaluation of total of 125 compounds for agonistic and antagonistic activity on AhR unveiled a low micromolar agonist, Cl2BPAF with an EC50 of 13 μM. Moreover, our study identified several AhR antagonists, with BrBzP emerging as the most potent with an IC50 of 8.9 μM. To further investigate the functional implications of these compounds, we subjected the most potent agonist and antagonist to a functional assay involving cytokine secretion from peripheral blood mononuclear cells and compared their activity with the commercially available agonist and antagonist. Cl2BPAF exhibited an overall immunosuppressive effect by reducing the secretion of proinflammatory cytokines, including IL-6, IFN-γ, and TNF-α, while BrBzP displayed opposite effects, leading to an increase of those cytokines. Notably, the immunomodulatory effects of Cl2BPAF surpassed those of ITE, a bona fide AhR agonist, while the impact of BrBzP exceeded that of CH223191, a bona fide AhR antagonist. In summary, our study underscores the potential influence of halogenated transformation products on the AhR pathway and, consequently, their role in shaping the immune responses.Source: Chemosphere. - ISSN 0045-6535 (Vol. 350, art. 141116, 2024, 9 str.)Type of material - article, component part ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 179509251
Author
Weiss, Veronika, farmacevtka |
Gobec, Martina, 1983- |
Jakopin, Žiga
Topics
Hormonski motilci |
Imunski odziv |
aryl hydrocarbon receptor |
halogenated transformation products |
parabens |
bisphenols |
UV filters |
cytokine release |
arilni ogljikovodikov receptor |
halogenirani transformacijski produkti |
parabeni |
bisfenoli |
UV filtri |
sprostitev citokinov
Author | Weiss, Veronika, farmacevtka ; Gobec, Martina, 1983- ; Jakopin, Žiga |
Title | Halogenation of common phenolic household and personal care product ingredients enhances their AhR-modulating capacity |
Publication date | |
COBISS.SI-ID | 179509251 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution-NonCommercial 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Napredna imunološka zdravila in celični pristopi v farmaciji | P1-0420-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Young Researcher's programme | 54787 | ||
Ministry of Education, Science, and Sport (MIZŠ) and the European Regional Development Fund OP20.05187 RI-SI-EATRIS | MR51882 |
Ministrstvo za izobraževanje, znanost in šport |
Files that belong to the publication
Link |
---|
https://www.sciencedirect.com/science/article/pii/S0045653524000092 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=154020 |
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Weiss, Veronika, farmacevtka | 54787 |
Gobec, Martina, 1983- | 32034 |
Jakopin, Žiga | 26496 |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.