-
Tick-borne encephalitis vaccine breakthrough infections induce aberrant T cell and antibody responses to non-structural proteins [Elektronski vir]Aregay, Amare ...Tick-borne encephalitis virus (TBEV) vaccine breakthrough (VBT) infections are not uncommon in endemic areas. The clinical and immunological outcomes have been poorly investigated. We assessed the ... magnitude and specificity of virus-specific antibody and T cell responses after TBE in previously vaccinated subjects and compared the results with those of unvaccinated TBE patients and study subjects that received vaccination without VBT infection. Symptomatic TBEV infection of unvaccinated study subjects induced virus-specific antibody responses to the E protein and non-structural protein 1 (NS1) as well as T cell responses to structural and other non-structural (NS) proteins. After VBT infections, significantly impaired NS1-specific antibody responses were observed, while the virus-specific T cell responses to the NS proteins were relatively strong. VBT infection caused predominantly moderate to severe disease during hospitalization. The level of TBEV EDIII- and NS1-specific antibodies in unvaccinated convalescent patients inversely correlated with TBE severity and neurological symptoms early after infection.Source: npj vaccines [Elektronski vir]. - ISSN 2059-0105 (Vol. 9, [article no.] 141, 2024, str. 1-9)Type of material - e-articlePublish date - 2024Language - englishCOBISS.SI-ID - 203877635
Author
Aregay, Amare |
Slunečko, Jan, 1997- |
Korva, Miša |
Bogovič, Petra |
Resman Rus, Katarina |
Knap, Nataša, 1978- |
Beicht, Jana |
Kubinski, Mareike |
Saletti, Giulietta |
Avšič-Županc, Tatjana |
Strle, Franc, 1949-
Topics
tick-borne encephalitis |
vaccine |
T-cells |
klopni encefalitis |
cepivo |
T celice
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Aregay, Amare | ![]() |
Slunečko, Jan, 1997- | 55839 |
Korva, Miša | 30696 |
Bogovič, Petra | 27886 |
Resman Rus, Katarina | 35044 |
Knap, Nataša, 1978- | 28601 |
Beicht, Jana | ![]() |
Kubinski, Mareike | ![]() |
Saletti, Giulietta | ![]() |
Avšič-Županc, Tatjana | 10331 |
Strle, Franc, 1949- | 13301 |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.