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  • Vpliv aktivacije trombocitov na učinkovitost odstranjevanja levkocitov s filtracijo iz koncentriranih trombocitov : magistrsko delo = Influence of platelet activation on efficiency of leukocyte removal by filtration from platelet concentrates : master of science thesis
    Domanovič, Dragoslav
    Some adverse transfusion reactions can be prevented or minimized by the removal of sufficient numbers of leukocytes from blood components using leukoreduction filters. Adhesion of leukocytes to ... platelets activated by adherence to the fibers is the supplemental mechanism that can improve the efficiency of leukocyte removal from fresh erythrocyte concentrates or fresh whole blood. Fiber filter media for leukoreduction of platelet concentrates (KT) is designed not to bind and activate platelets. Recent studies showed that platelets activated during preparation and storage of platelet concentrates can adhere to filter fibers. Our hypothesis is that leukocytes can bind to platelets that are already adhered to filter material because of previous activation, which can improve the efficiency of leukocyte removal by filtration also from the platelet concentrates. The aim of the study was to determine wether the efficiency of leukocyte removal from KT depends on degreeof platelet activation in KT. To confirm our hypothesis we compared the efficiency of leukocyte removal by filtration in two groups of 40 units of platelet concentrates. In the first group (KTPK), platelet concentrates were prepared manually from whole blood and contained a higher portion of activatedplatelets per unit. In the second group (KTTF), platelet concentrateswere prepared by apheresis and contained a smaller portion of activated platelets per unit. (Abstract truncated at 2000 characters)
    Type of material - master's thesis
    Publication and manufacture - Ljubljana : [D. Domanovič], 2000
    Language - slovenian
    COBISS.SI-ID - 2246420

Library Call number – location, accession no. ... Copy status
MF, Central Medical Library, Lj. magistrske naloge
DOMANOVIČ Dragoslav Vpliv
IN: 020010197 		available - outside loan, loan period: 1 months
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