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  • Vpliv sulfidolevkotrienov na patogenezo kronične urtikarije
    Šubic, Tjaša
    Background: In most cases the cause of chronic urticaria (CU) remains unknown - chronic idiopathic urticaria (CIU). The most important mediator is histamin and antihistamines are the main drugs used. ... They alleviate pruritus and decrease the incidence of hives in most patients with CIU. However, all patients do not respond to this therapy and some of them benefit from therapy wilh antileukotrienes. Beside histamine, arachidonic acid metabolites - sulphidoleukotrienes (sLT) are also important mediators of allergic reactions.Their role in the evolution of CIU is not yet known. AimsČ In a prospective manner we tried to find out if the response of our patients with CLU to antileukotriene therapy correlates with sulphidoleukotriene (sLT) concentration in leukocite suspension after different stimulations oržand withbasophils activation Subject and methods: The data were obtained from patients we diagnosed and treated for CIU in the years 1999 and 2000. We selected those who had symptoms in spite of antihistamine treatment. In a double blind crossover manner those patients took antileukotriene (montelukast10 mg per day) or placebo. Efficacy was assessed by pruritus score, number of wheals per day and sleep interference. We defined a subgroup of very severe urticaria as at least 30% higher symptom score than the mean score of the whole group. We compared the ability of leukocites of patients and healthy controls to release sLT (ELISA assay) and portion of activated basophils (flow citomerty) through receptor dependent (anti-IgE, unti-FCeRI, C5a) and non-dependent (ionomycine) stimulation. (Abstract truncated at 2000 characters)
    Type of material - master's thesis
    Publication and manufacture - Ljubljana : [T. Šubic], 2004
    Language - slovenian
    COBISS.SI-ID - 2757140

Library Call number – location, accession no. ... Copy status
MF, Central Medical Library, Lj. magistrske naloge
ŠUBIC Tjaša Vpliv
IN: 020050248 		available - outside loan, loan period: 1 months
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