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Zavora renin-angiotenzin-aldosteronskega sistema (RAAS) - več kot le zdravljenje hipertenzije? = Renin angiotensin aldosterone system (RAAS) blockade - more than antihypertensive treatment?Hojs, RadovanArterijska hipertenzija je ena najpogostejših kroničnih bolezni v razvitem svetu in je vodilni dejavnik tveganja za bolezni srca, možgansko kap in ledvično odpoved. Obstaja linearna povezava med ... krvnim tlakom in tveganjem za nastanek srčnožilnih bolezni. Raziskave so potrdile, da z znižanjem krvnega tlaka znižamo verjetnost za koronarne dogodke in možgansko kap. Povezava med krvnim tlakom in ledvičnimi boleznimi je zapletena. Ledvična bolezen je lahko vzrok hipertenzije, ledvice pa so tudi eden glavnih tarčnih organov pri hipertenziji. Hipertenzija je pogost vzrok nadaljnjega napredovanja ledvične odpovedi. Z znižanjem krvnega tlaka lahko upočasnimo ali celo ustavimo nadaljnje popuščanje delovanja ledvic. S slabšanjem delovanja ledvic se linearno povečuje tudi tveganje za srčnožilne zaplete in umrljivost. Renin-angiotenzin-aldosteronski sistem (RAAS) ima pomembno vlogo pri uravnavanju krvnega tlaka in homeostazi vode. Zdravila, ki zavrejo delovanje RAAS, imajo pričakovano odličen antihipertenzivni učinek. Številne eksperimentalne in klinične raziskave pa so dokazale, da je učinek zavore RAAS večji, kot bi pričakovali le zaradi znižanja krvnega tlaka. To so potrdili pri bolnikih s srčnožilnimi dogodki (miokardni infarkt, srčno popuščanje), možgansko kapjo in kronično ledvično boleznijo.Source: [Zbornik predavanj] (Letn. 49, supl. 1, mar. 2010, str. 11-15)Type of material - conference contribution ; adult, seriousPublish date - 2010Language - slovenianCOBISS.SI-ID - 3587135
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Hojs, Radovan | 15751 |
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