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Katepsin X kot kazalec napovedi preživetja in odziva na terapijo pri bolnikih s kolorektalnim rakom [Elektronski vir]Vižin, Tjaša ...Katepsin X je cisteinska proteaza, udeležena v procese napredovanja raka. Tumorske celice ga izločajo v zunajcelično tekočino v obliki proencima, njegove vrednosti pa bi lahko napovedale potek ... bolezni bolnikov z rakom. V prospektivni klinični študiji, ki je zajemala 264 bolnikov s kolorektalnim rakom, smo izmerili serumske vrednosti celokupnega katepsina X. Vzorce krvi smo odvzeli pred predoperativno kolonoskopijo in s testom ELISA izmerili vrednosti katepsina X v serumu. Kot kontrolno skupino smo naključno izbrali 77 osebkov z negativnimi rezultati pri kolonoskopiji. Vrednosti katepsina X v serumu bolnikov s kolorektalnim rakom niso bile višje od vrednosti v zdravih kontrolah, so pa bile povišane in povezane s krajšim preživetjem v skupini bolnikov s kolorektalnim rakom I.-III. stopnje, ki niso prejeli kemoterapije. Pri bolnikih, ki so prejeli kemoterapijo, pa te povezave ni bilo. Slednje pomeni, da vrednosti katepsina X lahko napovejo preživetje, pa tudi odziv bolnikov s kolorektalnim rakom na kemoterapijo.Source: 6. Jesenovčevi dnevi - raziskovalni dnevi laboratorijske biomedicine, 20. september 2014, Ljubljana [Elektronski vir] : zbornik predavanj (Str. 140-151)Type of material - conference contributionPublish date - 2014Language - slovenianCOBISS.SI-ID - 3715953
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Vižin, Tjaša | 34507 |
Christensen, Jarle | |
Wilhelmsen, Michael | |
Nielsen, Hans Jørgen | |
Kos, Janko, 1959- | 04648 |
Source: Personal bibliographies
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