Evaluation of the tablet surface flow velocities within pan coaters with implication to process understanding [Elektronski vir]
Dreu, Rok ...
Tablet pan coating process can be performed in different transverse tablet bedmotions, ranging from rolling to cascading. Satisfactory results in terms of coating performance should be maintained ...during scale-up. In order to achieve this goal in a controlled manner one should understand the dynamics of the pan coating process. The aim of this study was to establish a methodology for estimation of tablet translational surface velocities within a fully operational pan coater and to assess dependence of tablet translational velocities on tablet drum filling degree, pan speed, presence of baffles and selected tablet properties. Experiments were conducted on lab-scale and pilot-scale side-vented pan coaters. Biconvex two-layer tablets were assessed before, during and after the process of active coating. In order to determine tablet surface flow velocities a high-speed video of tablet surface flow was recorded via a borescope inserted in the coating drum and then analysed by cross-correlation algorithm. Obtained tablet velocity data were arranged in a linear fashion as a function of coating drum radius and frequency. Velocity data obtained during active coating were close to those of dry tablets after coating. Filling degree had little influence on the tablet velocity profile, when coating drum with baffles was used, while omission of baffles facilitated dependence velocity profile on the filling degree. Tablets with lower angle of repose exhibited velocity profiles with lower slopes than tablet samples with higher inter-tablet friction, but not in all cases. This particular behaviour can be explained by values of tablet bed dynamic angles of repose.
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