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Izkušnje pri kliničnem testiranju in uporabi humanega rekombinantnega eritropoetina (r-Hu-EPO) = Experiences with clinical testing and usage of recombinant human erythropoietin (r-Hu-EPO)Kveder, Radoslav ; Bren, Andrej ; Varl, Janez, nefrologAnaemia remains one of the most common signs of chronic renal failure (CRF). The advent of recombinant human erythropoietin (r-Hu-EPO) can be considered as one of the major and most important ... advances over the past decade in the treatment of CRF. Authors present their experiences of short clinical trial with a use of r-Hu-EPO omega. The aim of the study was to check safety and tolerability of the drug. Thirty patients aged 23 to 85 years treated with hemodialysis or CAPD with haemoglobin concentration lower than 85 g/l participated in the trial. Epoetin omega was administered subcutaneously two to three times weekly in an average dose of 25 to 75 IU/kg of body weight. Results showed an average rise of haemoglobin concentration to target value with an average weekly dose of 93 +- 6.7 IU/kg of body weight. Only 10.7 percent did not reach the target haemoglobin concentration of 100 g/l. An important rise of reticulocytes appeared in the third week of treatment period (from 23.6 +- 3.4 to 49. +- 6 percent. Significant rise of serum concentrations of iron and feritin was observed during second month of the study. Authors did not observe any important rise of blood pressure. Allergic reaction appeared in only one patient; no other adverse effects were noticed during study period. Authors concluded that treatment of renal anaemia in patients with CRF with r-Hu-EPO omega on short term is save and effective.Source: Farmacevtska oskrba in rekombinantna zdravila = Pharmaceutical care and combinant drugs : program (str. 163-171)Type of material - conference contributionPublish date - 1996Language - slovenianCOBISS.SI-ID - 4506585
Author
Kveder, Radoslav |
Bren, Andrej |
Varl, Janez, nefrolog
Topics
Erythropoietin |
Anemia |
Drug therapy |
Kidney failure, chronic |
Clinical trials |
Hemoglobins |
Blood pressure |
Iron |
Blood |
Ferritin |
Blood |
anemija |
eritropoetin |
r-Hu-EPO
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Kveder, Radoslav | 01982 |
Bren, Andrej | 01972 |
Varl, Janez, nefrolog | 08767 |
Source: Personal bibliographies
and: SICRIS
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