Vpliv procesnih parametrov kompaktiranja in sestave kompaktata na sproščanje karvedilola iz ogrodnih tablet s hipromelozo = Effects of roller compaction process parameters and compactat composition on release of carvedilol from matrix tablets with hypromellose : magistrski študijski program Industrijska farmacija
Brec, Tina, farmacevtka
Kompaktiranje je enostaven in hiter postopek suhega granuliranja, ki izboljša fizikalne, mehanske in/ali kemijske lastnosti zmesi. Zaradi napredka v opremi in številnih prednosti z vidika proizvodnih ...stroškov in stabilnosti izdelkov postaja vse bolj popularno v farmacevtski industriji. V magistrski nalogi smo preučevali vpliv procesnih parametrov kompaktiranja (sila stiskanja, hitrost valjev, tip sejalnika, velikost odprtin sita in površina mreže sita) in sestave kompaktata (različni deleži hipromeloze z vsebnostjo pretežno fragmentirajočega ali plastičnega polnila) na izbrane fizikalne in mehanske lastnosti granulata ter na sproščanje modelne zdravilne učinkovine karvedilol iz ogrodnih tablet s podaljšanim sproščanjem na osnovi hipromeloze izdelanih s postopkom kompaktiranja. Ugotovili smo, da lahko s sestavo zmesi in s procesnimi parametri kompaktiranja vplivamo na partikulatne lastnosti granul in da je vpliv procesnih parametrov kompaktiranja odvisen od mehanskih lastnosti materialov. Vpliv partikulatnih lastnosti granul se izrazi tudi pri sproščanju karvedilola iz ogrodnih tablet na osnovi hipromeloze, na sproščanje karvedilola iz ogrodnih tablet pa vpliva tudi sila tabletiranja.
Type of material - master's thesis
; adult, serious
Publication and manufacture - Ljubljana : [T. Brec], 2019
Knjižnica mind 661 BREC TINA Vpliv 138 IN: 0016189
available - reading room
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