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Stabilnost kanabidiola in ostalih kanabinoidov v rastlinskih oljih in maslih = Stability of cannabidiol and other cannabinoids in vegetable oils and buttersSebanc, PeterKonoplja (Cannabis sativa L.) je rastlina, ki je vse bolj zanimiva za farmacevtsko, prehransko in kozmetično industrijo, saj vsebuje različne sekundarne metabolite, med katerimi so najpomembnejši ... kanabinoidi, ki blagodejno vplivajo na različne fiziološke procese pri ljudeh in živalih. Ker v literaturi obstaja zelo malo podatkov o stabilnosti kanabinoidov, smo se v tej magistrski nalogi odločili, da preverimo, kakšna je njihova stabilnost v različnih rastlinskih oljih in maslih. Preverili smo stabilnost štirih različnih virov kanabinoidov, in sicer čistemu, izoliranemu kanabidiolu (CBD), izopropanolnemu ekstraktu konoplje, CO2 ekstraktu konoplje in konopljinim trihomom. Pri tem smo uporabili 4 različne lipofilne medije in sicer konopljino olje (z ali brez terpenov), olje s srednjeverižnimi maščobnimi kislinami, kokosovo olje in kakavovo maslo. Pri izopropanolnem ekstraktu in trihomih pa smo preverili stabilnost kanabinoidov tudi brez dodanega medija. Tako smo pripravili 14 različnih vzorcev v 2 paralelkah, ki smo jih postavili v improvizirano stabilnostno komoro (sušilnik za steklovino) na 40 °C. S HPLC analizno metodo smo nato določali vsebnost kanabinoidov ob pripravi vzorcev, po 34 dneh in po 99 dneh na temperaturi 40 °C. Pri tem smo preverjali spreminjanje koncentracije kanabinoidov CBD, CBDA, delta9-THC, CBN, CBG in CBC. Ugotovili smo, da se koncentracija kanabinoidov CBD, CBG in CBC le rahlo spreminjala iz česar lahko sklepamo, da so ti kanabinoidi stabilni. CBDA se je tekom staranja spreminjal v CBD, delta9-THC pa se je izkazal za najmanj stabilen kanabinoid, saj se je njegova koncentracija v večini vzorcev zmanjšala skoraj za polovico, posledično pa se je povečala koncentracija CBN vendar je pri tem nastal materialni primanjkljaj, s čimer smo dokazali, da pri razpadu delta9-THC ne nastane samo CBN temveč tudi drugi produkti.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [P. Sebanc], 2019Language - slovenianCOBISS.SI-ID - 4808561
Author
Sebanc, Peter
Other authors
Kreft, Samo |
Tavčar, Eva
Topics
konoplja |
kanabinoidi |
stabilnost |
lipofilna formulacija |
stabilnost delta THC |
stabilnost CBN
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Library | Call number – location, accession no. ... | Copy status |
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Faculty of Pharmacy, Lj. | Knjižnica mind 615.3 SEBANC PETER Stabilnost 153 IN: 0016345 |
available - reading room |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Sebanc, Peter | ![]() |
Kreft, Samo | 15460 |
Tavčar, Eva | 33335 |
Source: Personal bibliographies
and: SICRIS
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