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Immunomodulatory activity of IL-27 in human periapical lesionsČolić, Miodrag ...IL-27, a cytokine with pro-inflammatory and antiinflammatory properties, is a new member of the IL-6/IL-12 family, whose function in periapical lesions is unknown. We hypothesized that the production ... of IL-27 and its effect depend upon the type of immune/inflammatory response and clinical presentation of periapical lesions. We tested this hypothesis by studying the expression and function of IL-27 in human periapical lesions, both in situ and in culture. Immunohistochemistry demonstrated the strongest expression of IL-27 by endothelial cells and mononuclear phagocytes. Its production by periapical lesion mononuclear cells (PL-MNC), especially in symptomatic lesions, was significantly higher compared with that in peripheral blood MNC and correlated with the frequency of CD14+ and CD3+ cells. Exogenous IL-27 stimulated Th1 and down regulated Th17 cytokine production by PL-MNC from symptomatic lesions, but down-regulated Th1 and Th2 responses in asymptomatic lesions. These findings suggest that IL-27 is an immunomodulatory cytokine in periapical lesions, with complex biological effects.Source: Journal of dental research. - ISSN 0022-0345 (Vol. 88, no. 12, 2009, str. 1142-1147)Type of material - article, component partPublish date - 2009Language - englishCOBISS.SI-ID - 13596438
Author
Čolić, Miodrag |
Gazivoda, Dragan |
Majstorović, I. |
Dragicević, A. |
Vasilijić, Saša |
Rudolf, Rebeka |
Milosavljević, P. |
Vučević, Dragana
Topics
medicina |
periapikalna rana |
celična kultura |
konfokalna mikroskopija |
citokini |
dentalna medicina |
periapical lesion |
cell culture |
cytokine |
confocal microscopy |
T-helper cytokine
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Čolić, Miodrag | ![]() |
Gazivoda, Dragan | ![]() |
Majstorović, I. | ![]() |
Dragicević, A. | ![]() |
Vasilijić, Saša | ![]() |
Rudolf, Rebeka | 14335 |
Milosavljević, P. | ![]() |
Vučević, Dragana | ![]() |
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