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  • Vial wall effect on freeze-drying speed [Elektronski vir]
    Ramšak, Matjaž ; Hriberšek, Matjaž
    The vial wall thermal conductivity and thickness effect on freeze-drying speed is simulated. A 2D axisymmetric numerical simulation of Mannitol freeze-drying is employed using the boundary element ... method. The originality of the presented approach lies in the simulation of heat transfer in the vial walls as an additional computational domain in contrast to the typical methodology without a vial wall. The numerical model was validated using our measurements and the measurements from the literature. Increasing the glass vial thickness from 1 mm to 2 mm has been found as the major factor in primary drying time, increasing the gravimetrical Kv up to 20 % for all the simulated chamber pressures. The effect of thermal conductivity was simulated using a polymer and aluminium vial replacing the standard glass vial of the same thickness. The polymer vial‘s decreased Kv value is 5.6 % at a low chamber pressure of 50 mTorr, and 12.2 % at 400 mTorr, which is in excellent agreement with the experiment. Using higher conductivity materials, for example, aluminium, only 3.7 % and 2.3 % Kv increase were computed for low and high chamber pressures respectively.
    Source: Journal of pharmaceutical sciences [Elektronski vir]. - ISSN 1520-6017 (Vol. 113, iss. 5, May 2024, str. 1275-1284)
    Type of material - e-article ; adult, serious
    Publish date - 2024
    Language - english
    COBISS.SI-ID - 192744451

    Link(s):

    Digital Library of the University of Maribor – DLUM
    DOI

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