Kostne spremembe pri bolnikih z ledvično odpovedjo = Osseous changes in patients with renal failure
Pečovnik-Balon, Breda
It has been known for a long time that renal failure is also accompanied by osseous changes and increased parathyroid glands secondary hyperparathyroidism. The most significant causes are: disturbed ...metabolism of bivalent ions (Ca and P) and vitamin D. The absolute or relative lack of an active form of vitamin D-calcitriol is of essential significance to the genesis. In initial renal failure, a correlation exists between increased PTH concentration and decreased calcitriol concentration. Therefore the preventive administration of calcitriol is appropriate in case of increased PTH concentration, despite the absence of an osteopathic clinical picture small doses are administered orally. In simptomatic hyperparathyroidism, intermittent high oral or intravenius doses are administered since they proved to be more effective. Osseous changes may also be the resulst of aluminium intoxication. The only adequate treatment in this case is the elimination of aluminium from either water or phosphate binders.
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