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Gold nanoparticles in the engineering of antibacterial and anticoagulant surfacesEhmann, Heike M. A. ...Simultaneous antibacterial and anticoagulant surfaces have been prepared by immobilization of engineered gold nanoparticles onto different kinds of surfaces. The gold nanoparticle core is surrounded ... by a hemocompatible, anticoagulant polysaccharide, 6-O chitosan sulfate, which serves as reduction and stabilizing agent for the generation of gold nanoparticles in a microwave mediated reaction. The particle suspension shows anticoagulant activity, which is investigated by aPTT and PT testing on citrated blood samples of three patients suffering from congenital or acquired bleeding disorders. The amount of nanoparticles deposited on the surfaces is quantified by a quartz crystal microbalance with dissipation unit. All gold containing surfaces exhibit excellent antimicrobial properties against the chosen model organism, Escherichia coli MG 1655 [R1-16]. Moreover, blood plasma coagulation times of the surfaces are increased after deposition of the engineered nanoparticles as demonstrated by QCM-D.Source: Carbohydrate polymers. - ISSN 0144-8617 (Vol. 117, 2015, str. 34-42)Type of material - article, component partPublish date - 2015Language - englishCOBISS.SI-ID - 512439352
Author
Ehmann, Heike M. A. |
Breitwieser, Doris |
Winter, Sascha |
Gspan, Christian |
Koraimann, Günther |
Maver, Uroš, 1983- |
Šega, Marija |
Köstler, Stefan |
Stana-Kleinschek, Karin |
Spirk, Stefan |
Ribitsch, Volker
Topics
chitosan sulfate |
gold nanoparticles |
anticoagulant activity |
antimicrobial surfaces |
quartz crystal microbalance
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Ehmann, Heike M. A. | 33769 |
Breitwieser, Doris | |
Winter, Sascha | |
Gspan, Christian | |
Koraimann, Günther | |
Maver, Uroš, 1983- | 30850 |
Šega, Marija | 18032 |
Köstler, Stefan | |
Stana-Kleinschek, Karin | 07814 |
Spirk, Stefan | 34741 |
Ribitsch, Volker | 15077 |
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