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Hybrid 3D printing of advanced hydrogel-based wound dressings with tailorable properties [Elektronski vir]Milojević, Marko ...Despite the extensive utilization of polysaccharide hydrogels in regenerative medicine, current fabrication methods fail to produce mechanically stable scaffolds using only hydrogels. The recently ... developed hybrid extrusion-based bioprinting process promises to resolve these current issues by facilitating the simultaneous printing of stiff thermoplastic polymers and softer hydrogels at different temperatures. Using layer-by-layer deposition, mechanically advantageous scaffolds can be produced by integrating the softer hydrogel matrix into a stiffer synthetic framework. This work demonstrates the fabrication of hybrid hydrogel-thermoplastic polymer scaffolds with tunable structural and chemical properties for applications in tissue engineering and regenerative medicine. Through an alternating deposition of polycaprolactone and alginate/carboxymethylcellulose gel strands, scaffolds with the desired architecture (e.g., filament thickness, pore size, macro-/microporosity), and rheological characteristics (e.g., swelling capacity, degradation rate, and wettability) were prepared. The hybrid fabrication approach allows the fine-tuning of wettability (approx. 50-75°), swelling (approx. 0-20x increased mass), degradability (approx. 2-30+ days), and mechanical strength (approx. 0.2-11 MPa) in the range between pure hydrogels and pure thermoplastic polymers, while providing a gradient of surface properties and good biocompatibility. The controlled degradability and permeability of the hydrogel component may also enable controlled drug delivery. Our work shows that the novel hybrid hydrogel-thermoplastic scaffolds with adjustable characteristics have immense potential for tissue engineering and can serve as templates for developing novel wound dressings.Source: Pharmaceutics [Elektronski vir]. - ISSN 1999-4923 (Vol. 13, iss. 4, 2021, str. 1-24)Type of material - e-articlePublish date - 2021Language - englishCOBISS.SI-ID - 60048899
Author
Milojević, Marko |
Harih, Gregor |
Vihar, Boštjan |
Vajda, Jernej |
Gradišnik, Lidija, 1972- |
Zidarič, Tanja, 1987- |
Stana-Kleinschek, Karin |
Maver, Uroš, 1983- |
Maver, Tina
Topics
3D printing |
wound dressings |
alginate |
carboxymethyl cellulose |
polycaprolactone |
polysaccharide-based scaffolds
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Milojević, Marko | 50675 |
Harih, Gregor | 33256 |
Vihar, Boštjan | 50121 |
Vajda, Jernej | 54489 |
Gradišnik, Lidija, 1972- | 20420 |
Zidarič, Tanja, 1987- | 36420 |
Stana-Kleinschek, Karin | 07814 |
Maver, Uroš, 1983- | 30850 |
Maver, Tina | 33260 |
Source: Personal bibliographies
and: SICRIS
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