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Safety and efficacy of l-threonine produced by fermentation with Corynebacterium glutamicum for all animal species [Elektronski vir] : EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) : scientific opinionBampidis, Vasileios ...Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l-threonine produced by ... fermentation with Corynebacterium glutamicum when used as nutritional additive in feed and water for drinking for all animal species and categories. The product under assessment is l-threonine produced by fermentation with a genetically modified strain of C. glutamicum. The production strain and its recombinant DNA were not detected in the additive. The product l-threonine, manufactured by fermentation with C. gl does not give rise to any safety concern with regard to the production strain. l-Threonine produced using C. glutamicum is considered safe for the target species. The FEEDAP Panel has concerns regarding the safety of the simultaneous oral administration of l-threonine via water for drinking and feed. l-Threonine produced using C. glutamicum is safe for the consumer. The additive is not a skin or eye irritant and is not a skin sensitiser. Although the workers can be exposed by inhalation, the results of an acute inhalation study showed that risk of adverse effects by inhalation is low. l-Threonine produced using C. glutamicum is safe for the environment. The product under assessment is considered an efficacious source of the amino acid l-threonine for all animal species. For l-threonine to be as efficacious in ruminants as in non-ruminant species, it requires protection against degradation in the rumen.Source: EFSA journal [Elektronski vir]. - ISSN 1831-4732 (5603, Vol. 17, Iss. 3, Mar. 2019, 14 str.)Type of material - e-articlePublish date - 2019Language - englishCOBISS.SI-ID - 96535297
Author
Bampidis, Vasileios |
Azimonti, Giovanna |
Bastos, Maria de Lourdes |
Christensen, Henrik |
Dusemund, Birgit |
Kouba, Maryline |
Durjava, Mojca |
López-Alonso, Marta |
López Puente, Secundino |
Marcon, Francesca |
Mayo, Baltasar |
Pechová, Alena |
Petkova, Mariana |
Ramos, Fernando |
Sanz, Yolanda |
Villa, Roberto Edoardo |
Woutersen, Ruud |
Costa, Lucio G. |
Dierick, Noël Albert |
Flachowsky, Gerhard |
Glandorf, Boet |
Herman, Lieve |
Mantovani, Alberto |
Saarela, Maria |
Anguita, Montserrat |
Tarrés-Call, Jordi |
Wallace, John Robert, 1959-
Topics
nutritional additives |
amino acid |
L-threonine |
safety |
effcacy |
genetically modifedmicroorganism |
krma |
krmni dodatki |
aminokisline |
L-treonin |
gensko spremenjeni organizmi |
varnost |
učinkovitost
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Bampidis, Vasileios | ![]() |
Azimonti, Giovanna | ![]() |
Bastos, Maria de Lourdes | ![]() |
Christensen, Henrik | ![]() |
Dusemund, Birgit | ![]() |
Kouba, Maryline | ![]() |
Durjava, Mojca | 21878 |
López-Alonso, Marta | ![]() |
López Puente, Secundino | ![]() |
Marcon, Francesca | ![]() |
Mayo, Baltasar | ![]() |
Pechová, Alena | ![]() |
Petkova, Mariana | ![]() |
Ramos, Fernando | ![]() |
Sanz, Yolanda | ![]() |
Villa, Roberto Edoardo | ![]() |
Woutersen, Ruud | ![]() |
Costa, Lucio G. | ![]() |
Dierick, Noël Albert | ![]() |
Flachowsky, Gerhard | ![]() |
Glandorf, Boet | ![]() |
Herman, Lieve | ![]() |
Mantovani, Alberto | ![]() |
Saarela, Maria | ![]() |
Anguita, Montserrat | ![]() |
Tarrés-Call, Jordi | ![]() |
Wallace, John Robert, 1959- | ![]() |
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