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Diversity of MHC class II DRB alleles in the Northern chamois genus RupicapraStipoljev, Sunčica ...Major histocompatibility complex (MHC) genes are commonly used markers for monitoring adaptive genetic and evolutionary potential of species. In this study, we investigated genetic variation of the ... MHC class II DRB locus in the chamois genus Rupicapra by using next-generation sequencing. Sequencing of 102 samples led to the identification of 25 alleles, 11 of which are novel. The high ratio of the relative rates of nonsynonymous to synonymous mutations (dN/dS) suggests a signal of positive selection on this locus. We analyzed patterns of genetic variation within and among 2 subspecies of Northern Chamois and compared them to previously published studies using neutral markers to provide a basis for assessing the effects of demographic processes. Our analyses have shown that alleles are likely to be maintained by balancing selection in different populations with similar frequencies and that this mechanism also works in small, isolated populations that are strongly affected by genetic drift.Source: Journal of mammalogy. - ISSN 0022-2372 (Vol. 105, iss. 2, 2024, str. 312-322)Type of material - article, component part ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 185869315
Author
Stipoljev, Sunčica |
Bužan, Elena |
Iacolina, Laura |
Safner, Toni |
Rezić, Andrea |
Galov, Ana |
Križanović, Krešimir |
Ambarli, H. |
Bego, Ferdinand |
Gačić, Dragan P. |
Lazar, Peter, veterinar |
Maletić, Vladimir |
Markov, Georgi, biolog |
Papaioannou, Haritakis |
Scandura, Massimo |
Šprem, Nikica
Topics
allelic polymorphism |
major histocompatibility complex |
Rupicapra pyrenaica |
Rupicapra rupicapra |
alelni polimorfizem |
poglavitni histokompatabilni kompleks |
Rupicapra pyrenaica |
Rupicapra rupicapra |
gams
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Stipoljev, Sunčica | ![]() |
Bužan, Elena | 24375 |
Iacolina, Laura | 53817 |
Safner, Toni | ![]() |
Rezić, Andrea | ![]() |
Galov, Ana | ![]() |
Križanović, Krešimir | ![]() |
Ambarli, H. | ![]() |
Bego, Ferdinand | ![]() |
Gačić, Dragan P. | ![]() |
Lazar, Peter, veterinar | ![]() |
Maletić, Vladimir | ![]() |
Markov, Georgi, biolog | ![]() |
Papaioannou, Haritakis | ![]() |
Scandura, Massimo | ![]() |
Šprem, Nikica | ![]() |
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