To examine the correlations between forgiveness and well-being in mothers of children with disabilities, considering the moderating role of contextual factors. Well-being in mothers of children with disabilities is associated with coping with the numerous and unique challenges of motherhood. These are often accompanied by a sense of guilt, harm, and shame. Forgiveness can play an important role in lowering these negative emotions. The research was conducted with 174 mothers of children with disabilities, using the Emotional Forgiveness Scale; the Decision to Forgive Scale; and the Oxford Happiness Questionnaire. Contextual factorssuch as: severity of transgression, apology, and the quality of the relationship with the offender were also measured. Moderation analyses were used to examine the associations between the variables. Decisional and emotional forgiveness correlated positively with well-being. Contextual factors moderated only the relationship between emotional forgiveness and well-being. Severity of the transgression and apology had a moderating effect in the case of the Presence of positive emotions, and relationship quality in the case of Reduction of negative emotions. The well-being of mothers of children with disabilities is associated with both decisional and emotional forgiveness. Contextual factors are an important moderator of the relationship between emotional forgiveness and well-being in these mothers. Information about the importance of the relationship between forgiveness and well-being can be used to design therapeutic programs and programs supporting mothers of children with disabilities in coping with difficulties and achieving well-being. Such programs can incorporate, for example, forgiveness training. •The association between forgiveness and well-being in mothers of children with disabilities is moderated by contextual factors•The relationships between emotional forgiveness and well-being are moderated by contextual factors.•The model for emotional forgiveness: Reduction of negative emotions explains the variance in the psychological well-being of the mothers of children with disabilities better than the model: Presence of positive emotions.