E-resources
Peer reviewed
Open access
-
Subramanian, Anuradhaa; Nirantharakumar, Krishnarajah; Hughes, Sarah; Myles, Puja; Williams, Tim; Gokhale, Krishna M; Taverner, Tom; Chandan, Joht Singh; Brown, Kirsty; Simms-Williams, Nikita; Shah, Anoop D; Singh, Megha; Kidy, Farah; Okoth, Kelvin; Hotham, Richard; Bashir, Nasir; Cockburn, Neil; Lee, Siang Ing; Turner, Grace M; Gkoutos, Georgios V; Aiyegbusi, Olalekan Lee; McMullan, Christel; Denniston, Alastair K; Sapey, Elizabeth; Lord, Janet M; Wraith, David C; Leggett, Edward; Iles, Clare; Marshall, Tom; Price, Malcolm J; Marwaha, Steven; Davies, Elin Haf; Jackson, Louise J; Matthews, Karen L; Camaradou, Jenny; Calvert, Melanie; Haroon, Shamil
Nature medicine, 08/2022, Volume: 28, Issue: 8Journal Article
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is associated with a range of persistent symptoms impacting everyday functioning, known as post-COVID-19 condition or long COVID. We undertook a retrospective matched cohort study using a UK-based primary care database, Clinical Practice Research Datalink Aurum, to determine symptoms that are associated with confirmed SARS-CoV-2 infection beyond 12 weeks in non-hospitalized adults and the risk factors associated with developing persistent symptoms. We selected 486,149 adults with confirmed SARS-CoV-2 infection and 1,944,580 propensity score-matched adults with no recorded evidence of SARS-CoV-2 infection. Outcomes included 115 individual symptoms, as well as long COVID, defined as a composite outcome of 33 symptoms by the World Health Organization clinical case definition. Cox proportional hazards models were used to estimate adjusted hazard ratios (aHRs) for the outcomes. A total of 62 symptoms were significantly associated with SARS-CoV-2 infection after 12 weeks. The largest aHRs were for anosmia (aHR 6.49, 95% CI 5.02-8.39), hair loss (3.99, 3.63-4.39), sneezing (2.77, 1.40-5.50), ejaculation difficulty (2.63, 1.61-4.28) and reduced libido (2.36, 1.61-3.47). Among the cohort of patients infected with SARS-CoV-2, risk factors for long COVID included female sex, belonging to an ethnic minority, socioeconomic deprivation, smoking, obesity and a wide range of comorbidities. The risk of developing long COVID was also found to be increased along a gradient of decreasing age. SARS-CoV-2 infection is associated with a plethora of symptoms that are associated with a range of sociodemographic and clinical risk factors.
Author
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.