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Xie, Xuping; Liu, Yang; Liu, Jianying; Zhang, Xianwen; Zou, Jing; Fontes-Garfias, Camila R; Xia, Hongjie; Swanson, Kena A; Cutler, Mark; Cooper, David; Menachery, Vineet D; Weaver, Scott C; Dormitzer, Philip R; Shi, Pei-Yong
Nature medicine, 04/2021, Volume: 27, Issue: 4Journal Article
We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.
