Ibrutinib Regimens versus Chemoimmunotherapy in Older Patients with Untreated CLL

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Ibrutinib Regimens versus Chemoimmunotherapy in Older Patients with Untreated CLL

Woyach, Jennifer A; Ruppert, Amy S; Heerema, Nyla A; Zhao, Weiqiang; Booth, Allison M; Ding, Wei; Bartlett, Nancy L; Brander, Danielle M; Barr, Paul M; Rogers, Kerry A; Parikh, Sameer A; Coutre, Steven; Hurria, Arti; Brown, Jennifer R; Lozanski, Gerard; Blachly, James S; Ozer, Hatice G; Major-Elechi, Brittny; Fruth, Briant; Nattam, Sreenivasa; Larson, Richard A; Erba, Harry; Litzow, Mark; Owen, Carolyn; Kuzma, Charles; Abramson, Jeremy S; Little, Richard F; Smith, Scott E; Stone, Richard M; Mandrekar, Sumithra J; Byrd, John C

New England journal of medicine/The New England journal of medicine, 12/2018, Volume: 379, Issue: 26

Journal Article

Among older patients with untreated chronic lymphocytic leukemia, treatment with ibrutinib, either alone or in combination with rituximab, was superior to treatment with bendamustine plus rituximab with regard to progression-free survival. The two regimens that contained ibrutinib were equally effective.

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