Is Competition between Li+ and Mg2+ the Underlying Theme in the Proposed Mechanisms for the Pharmacological Action of Lithium Salts in Bipolar Disorder?

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Is Competition between Li+ and Mg2+ the Underlying Theme in the Proposed Mechanisms for the Pharmacological Action of Lithium Salts in Bipolar Disorder?

Mota de Freitas, Duarte; Castro, M. Margarida C. A; Geraldes, Carlos F. G. C

Accounts of chemical research, 04/2006, Volume: 39, Issue: 4

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Lithium salts have been in use for the treatment of bipolar disorder for more than 50 years, but their pharmacological mode of action remains a matter of conjecture. Li+ and Mg2+ share many physicochemical properties. Not surprisingly, many reported cellular targets for Li+ action involve Mg2+-activated enzymes, which are inhibited by Li+. In this Account, we describe results from our and other laboratories that suggest that a competition mechanism between Li+ and Mg2+ ions for Mg2+-binding sites in cellular components is the underlying theme in putative mechanisms of Li+ action.

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Mota de Freitas, Duarte | Castro, M. Margarida C. A | Geraldes, Carlos F. G. C

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