E-resources
-
Gupta, Aakriti; Madhavan, Mahesh V; Sehgal, Kartik; Nair, Nandini; Mahajan, Shiwani; Sehrawat, Tejasav S; Bikdeli, Behnood; Ahluwalia, Neha; Ausiello, John C; Wan, Elaine Y; Freedberg, Daniel E; Kirtane, Ajay J; Parikh, Sahil A; Maurer, Mathew S; Nordvig, Anna S; Accili, Domenico; Bathon, Joan M; Mohan, Sumit; Bauer, Kenneth A; Leon, Martin B; Krumholz, Harlan M; Uriel, Nir; Mehra, Mandeep R; Elkind, Mitchell S V; Stone, Gregg W; Schwartz, Allan; Ho, David D; Bilezikian, John P; Landry, Donald W
Nature medicine, 07/2020, Volume: 26, Issue: 7Journal Article
Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These conditions include thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologic illnesses, ocular symptoms, and dermatologic complications. Given that ACE2, the entry receptor for the causative coronavirus SARS-CoV-2, is expressed in multiple extrapulmonary tissues, direct viral tissue damage is a plausible mechanism of injury. In addition, endothelial damage and thromboinflammation, dysregulation of immune responses, and maladaptation of ACE2-related pathways might all contribute to these extrapulmonary manifestations of COVID-19. Here we review the extrapulmonary organ-specific pathophysiology, presentations and management considerations for patients with COVID-19 to aid clinicians and scientists in recognizing and monitoring the spectrum of manifestations, and in developing research priorities and therapeutic strategies for all organ systems involved.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.