Mesoionic xanthine analogs as inhibitors of cyclic AMP phosphodiesterase

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Mesoionic xanthine analogs as inhibitors of cyclic AMP phosphodiesterase

Glennon, R A; Rogers, M E; Bass, R G; Ryan, S B

Journal of pharmaceutical sciences, December 1978, Volume: 67, Issue: 12

Journal Article

Several derivatives of two mesoionic xanthine analogs, mesoionic thiazolo3,2-alphapyrimidine-5,7-diones and mesoionic 1,3,4-thiadiazolo3,2-alphapyrimidine-5,7-diones, were synthesized and evaluated as inhibitors of cyclic AMP phosphodiesterase. A significant number of these compounds demonstrated theophylline-like activity.

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Glennon, R A | Rogers, M E | Bass, R G | Ryan, S B

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