Health-related Quality of Life (HRQL) measures are widely used in research settings, but integration of use in routine clinical care has been slow. In spite of an increased effort to show its usefulness in a clinical setting, there is still an inherent need to better understand what patient-centered constructs would be best suited for integration into standard clinical care to enhance the measurement of HRQL-particularly in a HIV/AIDS population. This is a secondary data analysis that used structural equation modeling (SEM) to assess the utility of the HIV Cost and Services Utilization (HCSUS) in predicting health related quality of life (HRQL) in an AIDS-infected population in care. A model of hypothesized relationships between constructs was proposed and tested using EQS (version 6.1). A parsimonious model was achieved. The direct predictors of HRQL included medication adherence (β= 3.396; p<.05) and utilization of services (β=-18.184; p<.05). The final model had an acceptable fit with the measured data (χ2=171.4, p<.001, RMSEA=.06; CFI=.645). The results provide important information on the role of patient-centered constructs in health status decision-making. The analysis indicates that integration of these constructs should be investigated further with an emphasis on medication adherence and the use of health care services and how these two factors build on the AIDS patient's self-efficacy.