Synthesis and evaluation of alpha-hydroxythiol esters as antitumor agents and glyoxalase I inhibitors

E-resources

Peer reviewed

Synthesis and evaluation of alpha-hydroxythiol esters as antitumor agents and glyoxalase I inhibitors

Hall, S S; Doweyko, L M; Doweyko, A M; Zilenovski, J S

Journal of medicinal chemistry, 10/1977, Volume: 20, Issue: 10

Journal Article

Synthesis of a series of alpha-hydroxythiol esters made available, for the first time, product-like molecules that were evaluated as inhibitors of the enzyme glyoxalase I and as potential antitumor agents. All the alpha-hydroxythiol esters tested were competitive inhibitors of the enzyme, albeit weak; however, the relative I50 values suggested information about the active site. Antileukemic activity in L1210 lymphoid leukemia indicated no significant activity by these alpha-hydroxythiol esters.

Keep searching

Author

Hall, S S | Doweyko, L M | Doweyko, A M | Zilenovski, J S

Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.

Year	Impact factor		Edition		Category		Classification
Year	JCR	SNIP	JCR	SNIP	JCR	SNIP	JCR	SNIP

Links to authors' personal bibliographies	Links to information on researchers in the SICRIS system

Source: Personal bibliographies and: SICRIS

Upload image

Shelf entry

Adding material to shelf was successful.

Adding material to shelf failed.

It was not necessary to add the material to the shelf.

Permalink

E-mail

Impact factor

Select the library membership card:

DRS, in which the journal is indexed

Citations

Theme