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Palefsky, Joel M; Giuliano, Anna R; Goldstone, Stephen; Moreira, Edson D; Aranda, Carlos; Jessen, Heiko; Hillman, Richard; Ferris, Daron; Coutlee, Francois; Stoler, Mark H; Marshall, J. Brooke; Radley, David; Vuocolo, Scott; Haupt, Richard M; Guris, Dalya; Garner, Elizabeth I.O
New England journal of medicine/The New England journal of medicine, 10/2011, Volume: 365, Issue: 17Journal Article
Infection with human papillomavirus (HPV) serotypes 16 and 18 in men who have sex with men is a cause of considerable morbidity associated with anal intraepithelial neoplasia. This study shows that the HPV vaccine decreases the risk of HPV-associated anal disease. Anal cancer is biologically similar to cervical cancer, including having a causal relationship with human papillomavirus (HPV) infection. 1 Although HPV type 6 (HPV-6) or HPV type 11 (HPV-11) alone is rarely causal, the proportion of anal cancers associated with infection with HPV type 16 (HPV-16) or HPV type 18 (HPV-18) is as high as or higher than the proportion of cervical cancers. 1 Just as cervical cancer is preceded by high-grade cervical intraepithelial neoplasia (grade ≥2), anal cancer is preceded by high-grade anal intraepithelial neoplasia (grade 2 or 3). 2 – 4 Although not yet formally demonstrated, prevention or treatment of high-grade anal . . .
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