In this trial involving patients with intracerebral hemorrhage, intensive BP lowering (target systolic BP <140 mm Hg) did not significantly reduce the rate of the primary outcome of death or major disability but did significantly improve overall functional outcomes. Acute intracerebral hemorrhage, which is the least treatable form of stroke, affects more than 1 million people worldwide annually, 1 , 2 with the outcome determined by the volume and growth of the underlying hematoma. 3 – 5 Blood pressure often becomes elevated after intracerebral hemorrhage, 6 frequently reaching very high levels, and is a predictor of outcome. 7 – 11 On the basis of the results of the pilot-phase study, Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial 1 (INTERACT1), 12 – 14 we conducted the main-phase study, INTERACT2, 15 to determine the safety and effectiveness of early intensive lowering of blood pressure in patients with intracerebral hemorrhage. . . .