Researchers often lack knowledge about how to deal with outliers when analyzing their data. Even more frequently, researchers do not pre-specify how they plan to manage outliers. In this paper we aim to improve research practices by outlining what you need to know about outliers. We start by providing a functional definition of outliers. We then lay down an appropriate nomenclature/classification of outliers. This nomenclature is used to understand what kinds of outliers can be encountered and serves as a guideline to make appropriate decisions regarding the conservation, deletion, or recoding of outliers. These decisions might impact the validity of statistical inferences as well as the reproducibility of our experiments. To be able to make informed decisions about outliers you first need proper detection tools. We remind readers why the most common outlier detection methods are problematic and recommend the use of the median absolute deviation to detect univariate outliers, and of the Mahalanobis-MCD distance to detect multivariate outliers. An R package was created that can be used to easily perform these detection tests. Finally, we promote the use of pre-registration to avoid flexibility in data analysis when handling outliers.   'Publishers note: due to a typesetting error, this paper was originally published with incorrect table numbering, where tables 2, 3, and 4 were incorrectly labelled. This was corrected soon after publication.'