E-resources
Peer reviewed
-
Nowakowski, Mark; Tishler, Max; Doweyko, Arthur M.
Phosphorus, sulfur, and silicon and the related elements, 10/1989, Volume: 45, Issue: 3-4Journal Article
The phosphonate analogues of methionine and buthionine sulfoximide were synthesized by the action of NaN 3 on the corresponding sulfoxides. Analogues 3 and 4 were prepared to determine the effect of altering the carboxyl portion of known inhibitors in the glutamate synthase cycle. Results of biological testing revealed that 3 and 4 did not posses the potency found with buthionine and methionine sulfoximide in cellular systems. However 3 was found to be an effective and irreversible inhibitor of glutamine synthetase.
