Design, synthesis, and insecticidal activities of novel diamide derivatives with alpha‐amino acid subunits

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Design, synthesis, and insecticidal activities of novel diamide derivatives with alpha‐amino acid subunits

Chen, Rui‐Jia; Wang, Jun‐Jie; Han, Li; Gu, Yu‐Cheng; Xu, Zhi‐Ping; Cheng, Jia‐Gao; Shao, Xu‐Sheng; Xu, Xiao‐Yong; Li, Zhong

Journal of heterocyclic chemistry, July 2021, Volume: 58, Issue: 7

Journal Article

A series of diamide derivatives containing α‐amino acids were designed and synthesized. These compounds were evaluated for their insecticidal activities against Plutella xylostella, Mythimna separate, Myzus persicae, and Tetranychus cinnabarinus. Most of the title compounds containing an l‐phenylglycine skeleton were endowed with good activities at the concentration of 500 mg·L−1. Compounds (R)‐A6 showed a potential value for further optimization as an insecticidal lead with the LC50 value of 86.8 mg·L−1.

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